(4S)-4-hydroxy-L-proline hydrochloride

Base Information

• Chemical Name: (4S)-4-hydroxy-L-proline hydrochloride
• CAS No.: 441067-49-8
• Molecular Formula: C₅H₉NO₃*ClH
• Molecular Weight: 167.592
• Mol file: 441067-49-8.mol

Synonyms:Cis-4-hydroxy-L-proline monohydrochloride;

Chemical Property of (4S)-4-hydroxy-L-proline hydrochloride

Chemical Property:

• Vapor Pressure: 6.22E-07mmHg at 25°C
• Boiling Point: 368.6°C at 760 mmHg
• Flash Point: 176.7°C
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

cis-4-Hydroxy-L-prolineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4S)-4-hydroxy-L-proline hydrochloride

There total 9 articles about (4S)-4-hydroxy-L-proline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4R-4-hydroxyproline (51-35-4,30724-02-8) → (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride (77449-94-6,441067-49-8)

Guidance literature:

4R-4-hydroxyproline; With acetic anhydride; acetic acid; for 5.5h; Reflux; Inert atmosphere;

With hydrogenchloride; water; for 3h; Reflux;

DOI:10.1021/jo802344t

Reference yield: 84.2%

→ (2R,4S)-2-carboxy-4-hydroxy pyrrolidine hydrochloride (441067-49-8)

Guidance literature:

Reference yield: 71.0%

(2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate (135042-17-0) → (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride (142347-81-7,441067-49-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1021/ja3109664

upstream raw materials:

4R-4-hydroxyproline

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

(1R,4R)-5-acetyl-2-oxa-5-azabicyclo[2.2.1]heptan-3-one

1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate

Downstream raw materials:

1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

(2S,4S)-4-hydroxy-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl ester)

(2S,4R)-1-(3-ethoxybenzoyl)-4-hydroxypyrrolidine-2-carboxylic acid

Cbz-Pro-Hyp-Gly-OBn