4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

Base Information

• Chemical Name: 4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine
• CAS No.: 1037479-36-9
• Molecular Formula: C6H4Cl2N4S
• Molecular Weight: 235.097
• Hs Code.: 2933990090
• Mol file: 1037479-36-9.mol

Synonyms:4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine;4,6-dichloro-3-(Methylsulfanyl)-1H-pyrazolo[3,4-d]pyriMidine

Chemical Property of 4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property:

• PKA: 6.71±0.43(Predicted)
• PSA: 79.76000
• Density: 1.74±0.1 g/cm3(Predicted)
• LogP: 2.38160

Purity/Quality:

97% ^*data from raw suppliers

4,6-Dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,6-Dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine is a pyrazolopyrimidine derivative, these compounds are potential Syk and Abl inhibitors for treating allergic and autoimmune diseases.

Technology Process of 4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

There total 1 articles about 4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (1037479-34-7) → 4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine (1037479-36-9)

Guidance literature:

With dmap; trichlorophosphate; at 100 ℃; Product distribution / selectivity; Cooling with ice;

Reference yield: 94.0%

4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine (1037479-36-9) + N-acetyl-p-phenylenediamine (122-80-5) → N-(4-(6-chloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenyl)acetamide (1037479-66-5)

Guidance literature:

With triethylamine; In ethanol; at 70 ℃; for 15h;

Reference yield: 89.0%

tert-butyl cis-4-aminocyclohexylcarbamate + 4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine (1037479-36-9) → t-butyl (cis-4-{[6-chloro-3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}cyclohexyl)carbamate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 20 ℃;

upstream raw materials:

3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Downstream raw materials:

3-(6-chloro-3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)benzonitrile

3-(Methylthio)-N₆-(4-morpholinophenyl)-N₄-(thiazol-2-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

N-(4-(6-chloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenyl)acetamide

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