6-(BROMOMETHYL)-4-CHLOROQUINAZOLINE

Base Information

• Chemical Name: 6-(BROMOMETHYL)-4-CHLOROQUINAZOLINE
• CAS No.: 153436-68-1
• Molecular Formula: C9H6BrClN2
• Molecular Weight: 257.51
• Hs Code.: 2933990090
• Mol file: 153436-68-1.mol

Synonyms:6-(BROMOMETHYL)-4-CHLOROQUINAZOLINE

Chemical Property of 6-(BROMOMETHYL)-4-CHLOROQUINAZOLINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 363.23°C at 760 mmHg
• Flash Point: 173.476°C
• PSA: 25.78000
• Density: 1.7g/cm³
• LogP: 3.17810
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

6-(Bromomethyl)-4-chloroquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(BROMOMETHYL)-4-CHLOROQUINAZOLINE

There total 5 articles about 6-(BROMOMETHYL)-4-CHLOROQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-chloro-6-methylquinazoline (58421-79-7) → 6-bromomethyl-4-chloro-quinazoline (153436-68-1)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 0.5h; Reflux;

DOI:10.1002/ardp.201200267

Reference yield:

4-chloro-6-methylquinzoline + 4-chloro-6-dibromomethylquinazoline → 6-bromomethyl-4-chloro-quinazoline (153436-68-1)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane;

Reference yield:

2-Amino-5-methylbenzoic acid (2941-78-8) → 6-bromomethyl-4-chloro-quinazoline (153436-68-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 4 h / Reflux

2: thionyl chloride / N,N-dimethyl-formamide / 6 h / Reflux

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 0.5 h / Reflux

With N-Bromosuccinimide; thionyl chloride; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1002/ardp.201200267

upstream raw materials:

4-chloro-6-methylquinazoline

2-Amino-5-methylbenzoic acid

6-methyl-4-hydroxyquinazoline

Downstream raw materials:

6-bromomethyl-4-(3'-methylanilino)quinazoline

2-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazolin-6-yl)methyl)isoindoline-1,3-dione

C₂₈H₂₆ClFN₄O₃S₂

C₂₁H₂₀ClFN₄O₂S₂

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