4-Amino-3,5-dimethylbenzenepropanol

Base Information

• Chemical Name: 4-Amino-3,5-dimethylbenzenepropanol
• CAS No.: 454476-59-6
• Molecular Formula: C11H17NO
• Molecular Weight: 179.25
• Mol file: 454476-59-6.mol

Synonyms:4-Amino-3,5-dimethylbenzenepropanol;

Chemical Property of 4-Amino-3,5-dimethylbenzenepropanol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.567
• Boiling Point: 331.278 °C at 760 mmHg
• PKA: 15.09±0.10(Predicted)
• Flash Point: 154.152 °C
• PSA: 46.25000
• Density: 1.048 g/cm³
• LogP: 2.39170
• Solubility.: Acetone, Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-3,5-dimethylbenzenepropanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Amino-3,5-dimethylbenzenepropanol

There total 5 articles about 4-Amino-3,5-dimethylbenzenepropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(4-Amino-3,5-dimethyl-phenyl)-prop-2-en-1-ol → 3-(4-amino-3,5-dimethyl-phenyl)-propan-1-ol (454476-59-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃;

DOI:10.1021/ma061032v

Reference yield:

(E)-3-(4-Amino-3,5-dimethyl-phenyl)-acrylic acid methyl ester → 3-(4-amino-3,5-dimethyl-phenyl)-propan-1-ol (454476-59-6)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminum hydride / tetrahydrofuran / 20 °C

2: hydrogen / Pd/C / ethyl acetate / 20 °C

With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;

DOI:10.1021/ma061032v

Reference yield:

4-bromo-2,6-dimethylphenylamine (24596-19-8) → 3-(4-amino-3,5-dimethyl-phenyl)-propan-1-ol (454476-59-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tri-o-tolyl phosphine; triethylamine / palladium acetate / toluene / 100 °C

2: lithium aluminum hydride / tetrahydrofuran / 20 °C

3: hydrogen / Pd/C / ethyl acetate / 20 °C

With lithium aluminium tetrahydride; hydrogen; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; palladium diacetate; In tetrahydrofuran; ethyl acetate; toluene; 1: Heck coupling;

DOI:10.1021/ma061032v

upstream raw materials:

4-bromo-2,6-dimethylphenylamine

2,6-dimethylaniline

Refernces

• 1、 Schrekker, Henri S.,Kotov, Vasily,Preishuber-Pflugl, Peter,White, Peter,Brookhart, Maurice. "Efficient slurry-phase homopolymerization of ethylene to branched polyethylenes using α-diimine nickel(II) catalysts covalently linked to silica supports". . p. 6341 - 6354. Retrieved 2007/10/03.