Amoxicillin Diketopiperazine (Mixture of Diastereomers)

Base Information

• Chemical Name: Amoxicillin Diketopiperazine (Mixture of Diastereomers)
• CAS No.: 94659-47-9
• Molecular Formula: C16H19N3O5S
• Molecular Weight: 365.41
• Hs Code.: 2934990002
• Mol file: 94659-47-9.mol

Synonyms:Amoxicillin Diketopiperazine(Mixture of Diastereomers);Amoxicillin Piperazine-2,5-dione;Amoxicillin Diketopiperazine;2,5-Amoxipiperazinedione;2-[5-(4-Hydroxyphenyl)-3,6-dioxo-2-piperazinyl]-5,5-dimethyl-4-thiazolidinecarboxylic Acid;amoxicillin (2R)-piperazine-2',5'-dione;

Chemical Property of Amoxicillin Diketopiperazine (Mixture of Diastereomers)

Chemical Property:

• Melting Point: >218°C (dec.)
• Boiling Point: 799.3±60.0 °C(Predicted)
• PKA: 1.94±0.60(Predicted)
• PSA: 160.04000
• Density: 1.391±0.06 g/cm3(Predicted)
• LogP: 0.82280
• Storage Temp.: -20?C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Heated)

Purity/Quality:

98%Min ^*data from raw suppliers

AmoxicillinDiketopiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The major metabolite of Amoxicillin (AMO)(A634235).

Technology Process of Amoxicillin Diketopiperazine (Mixture of Diastereomers)

There total 3 articles about Amoxicillin Diketopiperazine (Mixture of Diastereomers) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

amoxycillin trihydrate (26889-93-0,81030-75-3) → amoxicillin (2R)-piperazine-2',5'-dione (94659-47-9) + amoxicillin (2S)-piperazine-2',5'-dione (94659-47-9)

Guidance literature:

In various solvent(s); for 20h; Ambient temperature; pH=9.2;

DOI:10.1248/cpb.34.2239

Reference yield: 5.0%

amoxycillin trihydrate (26889-93-0,81030-75-3) → amoxicillin (2R)-piperazine-2',5'-dione (94659-47-9) + amoxicillin (2S)-piperazine-2',5'-dione (94659-47-9)

Guidance literature:

In various solvent(s); for 20h; Ambient temperature; pH=9.2;

DOI:10.1248/cpb.34.2239

Reference yield:

amoxicillin (2R)-piperazine-2',5'-dione (94659-47-9) → amoxicillin (2S)-piperazine-2',5'-dione (94659-47-9)

Guidance literature:

In various solvent(s); at 37 ℃; for 12h; Product distribution; pH=3; equilibrium of epimerization; different pH;

DOI:10.1248/cpb.34.2239

upstream raw materials:

amoxycillin trihydrate