4-Amino-2,6-dimethyl-8-(2’-deoxy-β-D-ribofuranosyl)-7(8H)-pteridone

Base Information

• Chemical Name: 4-Amino-2,6-dimethyl-8-(2’-deoxy-β-D-ribofuranosyl)-7(8H)-pteridone
• CAS No.: 195442-56-9
• Molecular Formula: C13H17N5O4
• Molecular Weight: 307.3052
• Mol file: 195442-56-9.mol

Synonyms:4-Amino-8-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2,6-dimethyl-pteridin-7-one;

Chemical Property of 4-Amino-2,6-dimethyl-8-(2’-deoxy-β-D-ribofuranosyl)-7(8H)-pteridone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: >190°C dec.
• Refractive Index: 1.782
• Boiling Point: 621.605 °C at 760 mmHg
• Flash Point: 329.735 °C
• Density: 1.759 g/cm³

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-2,6-dimethyl-8-(2’-deoxy-β-D-ribofuranosyl)-7(8H)-pteridone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A highly fluorescent adenosine analogue, which in a dimethoxytrityl, phosphoramidite protected form, can be site-specifically inserted into oligonucleotides through a 3’,5’-phosphodiester linkage using an automated DNA synthesizer.

Technology Process of 4-Amino-2,6-dimethyl-8-(2’-deoxy-β-D-ribofuranosyl)-7(8H)-pteridone

There total 1 articles about 4-Amino-2,6-dimethyl-8-(2’-deoxy-β-D-ribofuranosyl)-7(8H)-pteridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H23Cl2N5O6 → DMAP (195442-56-9)

Guidance literature:

With sodium methylate; In methanol; further reagent: K₂CO₃;

DOI:10.1080/07328319708002964

Reference yield:

DMAP (195442-56-9) → Succinic acid mono-{(2R,3S,5R)-5-(4-amino-2,6-dimethyl-7-oxo-7H-pteridin-8-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: 4-(dimethylamino)pyridine / CH₂Cl₂

With pyridine; dmap; In dichloromethane;

DOI:10.1080/07328319708002964

Reference yield:

DMAP (195442-56-9) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(4-amino-2,6-dimethyl-7-oxo-7H-pteridin-8-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: 1H-tetrazole / CH₂Cl₂

With pyridine; 1H-tetrazole; In dichloromethane;

DOI:10.1080/07328319708002964

Downstream raw materials:

4-Amino-8-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,6-dimethyl-8H-pteridin-7-one

Refernces