rac 4-Amino Deprenyl

Base Information

• Chemical Name: rac 4-Amino Deprenyl
• CAS No.: 217808-43-0
• Molecular Formula: C13H18N2
• Molecular Weight: 203.2881
• Mol file: 217808-43-0.mol

Synonyms:rac 4-Amino Deprenyl;4-AMino-N,α-diMethyl-N-2-propyn-1-ylbenzeneethanaMine

Chemical Property of rac 4-Amino Deprenyl

Chemical Property:

• Boiling Point: 334.9±27.0 °C(Predicted)
• PKA: 7.39±0.50(Predicted)
• Density: 1.057g/cm³

Purity/Quality:

98%Min ^*data from raw suppliers

rac4-AminoDeprenyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A structural analog of Deprenyl.

Technology Process of rac 4-Amino Deprenyl

There total 8 articles about rac 4-Amino Deprenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C18H26N2O2 → (R)-4-(2-(methyl(prop-2-yn-1-yl)amino)propyl)aniline (217808-43-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 8h;

DOI:10.1016/j.bmc.2015.04.009

Reference yield:

4-nitrobenzeneacetic acid (104-03-0) → (R)-4-(2-(methyl(prop-2-yn-1-yl)amino)propyl)aniline (217808-43-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: acetic anhydride / 6 h / 20 °C / Inert atmosphere

2.1: hydrogen; 5%-palladium/activated carbon / methanol

3.1: potassium carbonate / tetrahydrofuran; water / 0.08 h

3.2: 10 h

4.1: hydrogen; platinum on carbon / methanol / 24 h / 20 °C / 15001.5 Torr

5.1: hydrogen; 10% Pt/activated carbon / methanol / 12 h

6.1: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 40 °C / 11251.1 Torr

7.1: potassium carbonate / acetonitrile; toluene / 12 h / 20 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 8 h / 0 - 20 °C

With 10% Pt/activated carbon; 5%-palladium/activated carbon; palladium 10% on activated carbon; platinum on carbon; hydrogen; acetic anhydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;

DOI:10.1016/j.bmc.2015.04.009

Reference yield:

1-(4-nitrophenyl)propan-2-one (5332-96-7) → (R)-4-(2-(methyl(prop-2-yn-1-yl)amino)propyl)aniline (217808-43-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: hydrogen; 5%-palladium/activated carbon / methanol

2.1: potassium carbonate / tetrahydrofuran; water / 0.08 h

2.2: 10 h

3.1: hydrogen; platinum on carbon / methanol / 24 h / 20 °C / 15001.5 Torr

4.1: hydrogen; 10% Pt/activated carbon / methanol / 12 h

5.1: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 40 °C / 11251.1 Torr

6.1: potassium carbonate / acetonitrile; toluene / 12 h / 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 8 h / 0 - 20 °C

With 10% Pt/activated carbon; 5%-palladium/activated carbon; palladium 10% on activated carbon; platinum on carbon; hydrogen; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;

DOI:10.1016/j.bmc.2015.04.009

upstream raw materials:

4-nitrobenzeneacetic acid

1-(4-nitrophenyl)propan-2-one

1-(4-amino-phenyl)propan-2-one

Refernces