(S)-4-Aminobenzyl Ethylenediaminetetraacetic Acid Tetra(t-butyl) Ester

Base Information

• Chemical Name: (S)-4-Aminobenzyl Ethylenediaminetetraacetic Acid Tetra(t-butyl) Ester
• CAS No.: 143106-46-1
• Molecular Formula: C33H55N3O8
• Molecular Weight: 621.815
• Mol file: 143106-46-1.mol

Synonyms:(S)-4-Aminobenzyl Ethylenediaminetetraacetic Acid Tetra(t-butyl) Ester;N,N'-[(1S)-1-[(4-AMinophenyl)Methyl]-1,2-ethanediyl]bis[N-[2-(1,1-diMethylethoxy)-2-oxoethyl]glycine Bis(1,1-diMethylethyl) Ester

Chemical Property of (S)-4-Aminobenzyl Ethylenediaminetetraacetic Acid Tetra(t-butyl) Ester

Chemical Property:

• PSA: 137.70000
• LogP: 4.73190
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

(S)-4-AminobenzylEthylenediaminetetraaceticAcidTetra(t-butyl)Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-4-Aminobenzyl Ethylenediaminetetraacetic Acid Tetra(t-butyl) Ester

There total 3 articles about (S)-4-Aminobenzyl Ethylenediaminetetraacetic Acid Tetra(t-butyl) Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(S)-<<1-<amino>methyl>-2-(4-nitrophenyl)ethyl><(tert-butoxycarbonyl)methyl>amino>acetic acid tert-butyl ester → tetra-tert-butyl 2,2',2”,2”'-((3-(4-aminophenyl)propane-1,2-diyl)bis(azanetriyl))tetraacetate (143106-46-1)

Guidance literature:

With hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; at 25 ℃; for 20h; Product distribution / selectivity;

Reference yield:

3-(4-Nitrophenyl)propane-1,2-diamine (81677-62-5) → tetra-tert-butyl 2,2',2”,2”'-((3-(4-aminophenyl)propane-1,2-diyl)bis(azanetriyl))tetraacetate (143106-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / acetonitrile / 12 h / Reflux

2: palladium on activated charcoal / ethanol / 1 h / 760.05 Torr

With palladium on activated charcoal; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium iodide; In ethanol; acetonitrile;

Reference yield:

(2S)-2-amino-3-(4-nitrophenyl)propanamide (81677-61-4) → tetra-tert-butyl 2,2',2”,2”'-((3-(4-aminophenyl)propane-1,2-diyl)bis(azanetriyl))tetraacetate (143106-46-1)

Guidance literature:

Multi-step reaction with 3 steps

1: borane tetrahydrofuran / tetrahydrofuran / 24 h / 50 °C / Cooling with ice

2: sodium iodide; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / acetonitrile / 12 h / Reflux

3: palladium on activated charcoal / ethanol / 1 h / 760.05 Torr

With borane tetrahydrofuran; palladium on activated charcoal; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium iodide; In tetrahydrofuran; ethanol; acetonitrile;

upstream raw materials:

3-(4-Nitrophenyl)propane-1,2-diamine

(2S)-2-amino-3-(4-nitrophenyl)propanamide

Downstream raw materials:

C₃₆H₅₇N₃O₉