Chemical Property of ALX 5407 hydrochloride
Chemical Property:
- PSA：49.77000
- LogP:5.82130
- Storage Temp.:2-8°C
- Solubility.:DMSO: ~16 mg/mL, soluble
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:9
- Exact Mass:429.1506995
- Heavy Atom Count:30
- Complexity:481
- Purity/Quality:
-
99% *data from raw suppliers
NFPS hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn,N
- Hazard Codes:Xn,N
- Statements:
22-50/53
- Safety Statements:
22-24/25-61-60
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CN(CCC(C1=CC=C(C=C1)F)OC2=CC=C(C=C2)C3=CC=CC=C3)CC(=O)O.Cl
- Isomeric SMILES:CN(CC[C@H](C1=CC=C(C=C1)F)OC2=CC=C(C=C2)C3=CC=CC=C3)CC(=O)O.Cl
-
Uses
ALX 5407 Hydrochloride can be used in the preparation of amino acid derivatives as pharmaceuticals for treatment of neurological and neuropsychiatric disorders. ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.
