ALX 5407 hydrochloride

Base Information

• Chemical Name: ALX 5407 hydrochloride
• CAS No.: 200006-08-2
• Molecular Formula: C24H25ClFNO3
• Molecular Weight: 429.91
• European Community (EC) Number: 806-215-3
• DSSTox Substance ID: DTXSID60582019
• Mol file: 200006-08-2.mol

Synonyms:(R)-(N-(3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl))sarcosine;ALX 5407;ALX-5407

Chemical Property of ALX 5407 hydrochloride

Chemical Property:

• PSA: 49.77000
• LogP: 5.82130
• Storage Temp.: 2-8°C
• Solubility.: DMSO: ~16 mg/mL, soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 429.1506995
• Heavy Atom Count: 30
• Complexity: 481

Purity/Quality:

98%,99%, ^*data from raw suppliers

NFPS hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-50/53
• Safety Statements: 22-24/25-61-60

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CCC(C1=CC=C(C=C1)F)OC2=CC=C(C=C2)C3=CC=CC=C3)CC(=O)O.Cl
• Isomeric SMILES: CN(CC[C@H](C1=CC=C(C=C1)F)OC2=CC=C(C=C2)C3=CC=CC=C3)CC(=O)O.Cl
• Uses: ALX 5407 Hydrochloride can be used in the preparation of amino acid derivatives as pharmaceuticals for treatment of neurological and neuropsychiatric disorders. ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.