5-AMINO-2-CHLORO-2,3-DIHYDROTHIAZOLO[4,5-D]PYRIMIDINE-7-(6H)-ONE

Base Information

• Chemical Name: 5-AMINO-2-CHLORO-2,3-DIHYDROTHIAZOLO[4,5-D]PYRIMIDINE-7-(6H)-ONE
• CAS No.: 30161-95-6
• Molecular Formula: C₅H₃ClN₄OS
• Molecular Weight: 202.624
• Hs Code.: 2934999090
• Mol file: 30161-95-6.mol

Synonyms:5-Amino-2-chlorothiazolo[4,5-d]pyrimidin-7(4H)-one;5-AMino-2-chloro-thiazolo[4,5-d]pyriMidin-7(6H)-one;Thiazolo[4,5-d]pyriMidin-7(6H)-one, 5-aMino-2-chloro-;5-AMINO-2-CHLORO-2,3-DIHYDROTHIAZOLO[4,5-D]PYRIMIDINE-7-(6H)-ONE

Chemical Property of 5-AMINO-2-CHLORO-2,3-DIHYDROTHIAZOLO[4,5-D]PYRIMIDINE-7-(6H)-ONE

Chemical Property:

• Melting Point: >300°C
• Refractive Index: 2.029
• PKA: 7.42±0.20(Predicted)
• PSA: 113.89000
• Density: 2.303 g/cm³
• LogP: 0.95760
• Storage Temp.: Refrigerator
• Solubility.: DMF (Slightly, Heated, Sonicated), DMSO (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

5-Amino-2-chloro-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO-2-CHLORO-2,3-DIHYDROTHIAZOLO[4,5-D]PYRIMIDINE-7-(6H)-ONE

There total 1 articles about 5-AMINO-2-CHLORO-2,3-DIHYDROTHIAZOLO[4,5-D]PYRIMIDINE-7-(6H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-Diamino-7-hydroxy-thiazolo<4.5-d>pyrimidin (22288-77-3) → 5-amino-2-chloro-6H-thiazolo[4,5-d]pyrimidin-7-one (30161-95-6)

Guidance literature:

With hydrogenchloride; sodium nitrite; In sodium hydroxide; water;

DOI:10.1039/j39700002478

Reference yield:

5-amino-2-chlorothiazolo<4,5-d>pyrimidin-7(6H)-one (30161-95-6) → 5-amino-2,3-dihydro-2-thioxo-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)thiazolo<4,5-d>pyrimidin-7(6H)-one (122970-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaSH*H₂O / ethane-1,2-diol / 2 h / 110 °C

2: 1.) HMDS, (NH₄)2SO₄, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) pyridine, reflux, 4 h, 2a.) acetonitrile, RT, 16 h, 2b.) 70 deg C, 3 h

With ammonium sulfate; sodium hydrogensulfide; trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane; In ethylene glycol;

DOI:10.1021/jm00163a064

Reference yield:

5-amino-2-chloro-6H-thiazolo[4,5-d]pyrimidin-7-one (30161-95-6) → 5-amino-3H,6H-thiazolo[4,5-d]pyrimidine-2,7-dione (30161-97-8)

Guidance literature:

With sodium hydroxide;

DOI:10.1039/j39700002478

upstream raw materials:

2,5-Diamino-7-hydroxy-thiazolo<4.5-d>pyrimidin

Downstream raw materials:

5-amino-3H,6H-thiazolo[4,5-d]pyrimidine-2,7-dione

5-amino-2,3-dihydro-2-thioxo-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)thiazolo<4,5-d>pyrimidin-7(6H)-one

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