(2-methyl-1H-indol-5-yl)methanamine

Base Information

• Chemical Name: (2-methyl-1H-indol-5-yl)methanamine
• CAS No.: 36798-25-1
• Molecular Formula: C10H12N2
• Molecular Weight: 160.22
• Hs Code.: 2933990090
• European Community (EC) Number: 800-954-5
• DSSTox Substance ID: DTXSID80482784
• Wikidata: Q72492072
• Mol file: 36798-25-1.mol

Synonyms:36798-25-1;(2-methyl-1H-indol-5-yl)methanamine;(2-methyl-1h-indol-5-yl)methylamine;[(2-Methyl-1H-indol-5-yl)methyl]amine;1-(2-methyl-1H-indol-5-yl)methanamine;C-(2-Methyl-1H-indol-5-yl)methylamine;MFCD05864579;[(2-methyl-1H-indol-5-yl)methyl]amine hydrochloride;2-methyl-5-aminomethylin-dole;SCHEMBL6683148;DTXSID80482784;OZQPOLJBMYZUOL-UHFFFAOYSA-N;AKOS005172044;SB17630;NCGC00324975-01;AC-30786;AM803785;c-(2-methyl-1h-indol-5-yl)-methylamine;BB 0253920;CS-0038604;EN300-209649;AB01319687-02;(2-Methyl-1H-indol-5-yl)methanamine, AldrichCPR;F2143-0151

Chemical Property of (2-methyl-1H-indol-5-yl)methanamine

Chemical Property:

• Vapor Pressure: 7.13E-05mmHg at 25°C
• Boiling Point: 343.3°C at 760 mmHg
• Flash Point: 188.2°C
• PSA: 41.81000
• Density: 1.159g/cm³
• LogP: 2.63530
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 160.100048391
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

98%Min ^*data from raw suppliers

(2-Methyl-1H-indol-5-yl)methylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(N1)C=CC(=C2)CN
• Uses: (2-Methyl-1H-indol-5-yl)methylamine is used for preparation of substituted aminopyridines and aminopyrazines as protein kinase inhibitors.

Technology Process of (2-methyl-1H-indol-5-yl)methanamine

There total 8 articles about (2-methyl-1H-indol-5-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-methyl-1H-indole-5-carbonitrile (36798-24-0) → 5-Aminomethyl-2-methylindol (36798-25-1)

Guidance literature:

2-methyl-1H-indole-5-carbonitrile; With lithium aluminium tetrahydride; In tetrahydrofuran; at 5 - 7 ℃; for 1.5h; Reflux;

With water; sodium hydroxide; In tetrahydrofuran; for 0.166667h; Cooling with ice;

Reference yield: 92.0%

2-methyl-5-(phtalimidomethyl)indole (58867-56-4) → 5-Aminomethyl-2-methylindol (36798-25-1)

Guidance literature:

With hydrazine hydrate; In methanol; for 1.5h; Heating;

DOI:10.1007/BF00515025

Reference yield:

5-bromo-2-methyl-1H-indole (1075-34-9) → 5-Aminomethyl-2-methylindol (36798-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: quinoline / 1 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 5 - 7 °C / Reflux

2.2: 0.17 h / Cooling with ice

With lithium aluminium tetrahydride; In tetrahydrofuran; quinoline;

upstream raw materials:

2-methyl-5-(phtalimidomethyl)indole

2-methyl-1H-indole

1-benzenesulfonyl-1H-indole-5-carbonitrile

5-bromo-2-methyl-1H-indole