2-bromo-N-(2,5-dimethylphenyl)acetamide

Base Information

• Chemical Name: 2-bromo-N-(2,5-dimethylphenyl)acetamide
• CAS No.: 349120-88-3
• Molecular Formula: C10H12BrNO
• Molecular Weight: 242.115
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID90392269
• Wikidata: Q82190348
• Mol file: 349120-88-3.mol

Synonyms:2-bromo-N-(2,5-dimethylphenyl)acetamide;349120-88-3;2-BROMO-N-(2,5-DIMETHYL-PHENYL)-ACETAMIDE;DTXSID90392269;ZNA12088;MFCD02974356;STL067051;AKOS000319650;CS-0318025

Chemical Property of 2-bromo-N-(2,5-dimethylphenyl)acetamide

Chemical Property:

• PSA: 29.10000
• LogP: 2.70980
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 241.01023
• Heavy Atom Count: 13
• Complexity: 184

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

2-Bromo-N-(2,5-dimethylphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)C)NC(=O)CBr

Technology Process of 2-bromo-N-(2,5-dimethylphenyl)acetamide

There total 1 articles about 2-bromo-N-(2,5-dimethylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,5-Dimethylaniline (95-78-3) + 2-Bromoacetyl bromide (598-21-0) → 2-bromo-N-(2,5-dimethylphenyl)acetamide (349120-88-3)

Guidance literature:

With sodium carbonate; In water; pH=9 - 10;

DOI:10.1016/j.bioorg.2020.104525

Reference yield: 94.0%

2-bromo-N-(2,5-dimethylphenyl)acetamide (349120-88-3) + 5-(1-phenylcarbamoylpiperidine)-4H-1,3,4-oxadiazole-2-thiol → 2-(5-(1-phenylcarbamoylpiperidine)-4H-1,3,4-oxadiazole-2-ylthio)-N-2,5-dimethylphenylacetamide

Guidance literature:

5-(1-phenylcarbamoylpiperidine)-4H-1,3,4-oxadiazole-2-thiol; With potassium hydroxide; In ethanol; at 20 ℃; for 0.5h;

2-bromo-N-(2,5-dimethylphenyl)acetamide; In ethanol;

DOI:10.1016/j.bioorg.2021.105243

Reference yield: 94.0%

2-bromo-N-(2,5-dimethylphenyl)acetamide (349120-88-3) + 5-(4-chlorophenyl)-1,3,4-oxadiazole-2-thiol (23766-28-1,203268-67-1) → 2-[{5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl}sulfanyl]-N-(2,5-dimethylphenyl)acetamide

Guidance literature:

5-(4-chlorophenyl)-1,3,4-oxadiazole-2-thiol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2-bromo-N-(2,5-dimethylphenyl)acetamide; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

2,5-Dimethylaniline

2-Bromoacetyl bromide

Downstream raw materials:

ethoxy-acetic acid-(2,5-dimethyl-anilide)

2-[{5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl}sulphanyl]-N-(2,5-dimethylphenyl)acetamide

C₁₈H₁₆ClN₃O₂S