N-(2-Aminoethyl) Cyclopamine

Base Information

• Chemical Name: N-(2-Aminoethyl) Cyclopamine
• CAS No.: 334616-31-8
• Molecular Formula: C29H46N2O2
• Molecular Weight: 454.696
• Mol file: 334616-31-8.mol

Synonyms:(3S,3'aS,6'S,6aS,9R,11bR)-4'-(2-Aminoethyl)-3',6',10,11b-tetramethyl-spiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3,3a,5,6,7,7a-hexahydrofuro[3,2-b]pyridine]-3-ol. It is off-white solid. It is a deriviative of cyclopamine;

Chemical Property of N-(2-Aminoethyl) Cyclopamine

Chemical Property:

• Melting Point: 188-200°C
• Boiling Point: 589.514 °C at 760 mmHg
• PKA: 15.04±0.70(Predicted)
• Flash Point: 310.327 °C
• PSA: 58.72000
• Density: 1.15 g/cm³
• LogP: 5.31120
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

N-(2-Aminoethyl)Cyclopamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A deriviative of Cyclopamine, which demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1

Technology Process of N-(2-Aminoethyl) Cyclopamine

There total 1 articles about N-(2-Aminoethyl) Cyclopamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-glycylcyclopamine (334616-30-7) → N-aminoethylcyclopamine (334616-31-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Heating / reflux;

Reference yield: 62.0%

N-trifluoroacetyl-4-benzoylphenylalanine-N-hydroxysuccinimide ester (334616-58-9) + N-aminoethylcyclopamine (334616-31-8) → N-(N'-(N-trifluoroacetyl-4-benzoylphenylalanine)aminoethyl)cyclopamine

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 54.0%

N-aminoethylcyclopamine (334616-31-8) + 2,5-dioxopyrrolidin-1-yl 3-phenylpropanoate (109318-10-7) → N-(N'-dihydrocinnamoylaminoethyl)cyclopamine

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

N-glycylcyclopamine