Pyridine, 2-[(difluoromethyl)sulfonyl]-

Base Information

Chemical Name:Pyridine, 2-[(difluoromethyl)sulfonyl]-
CAS No.:1219454-89-3
Molecular Formula:C6H5F2NO2S
Molecular Weight:193.174
Hs Code.:29339900
Mol file:1219454-89-3.mol

Synonyms:Pyridine, 2-[(difluoroMethyl)sulfonyl]-;2-[(DifluoroMethyl)sulfonyl]pyridine;DifluoroMethyl 2-Pyridyl Sulfone

Suppliers and Price of Pyridine, 2-[(difluoromethyl)sulfonyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
2-((Difluoromethyl)sulfonyl)pyridine
5g
$ 249.00

Ambeed
2-((Difluoromethyl)sulfonyl)pyridine 98%
1g
$ 14.00

Ambeed
2-((Difluoromethyl)sulfonyl)pyridine 98%
5g
$ 48.00

Ambeed
2-((Difluoromethyl)sulfonyl)pyridine 98%
25g
$ 158.00

Apolloscientific
Difluoromethyl 2-pyridyl sulfone 97%
5g
$ 290.00

Apolloscientific
Difluoromethyl 2-pyridyl sulfone 97%
1g
$ 145.00

Chemenu
2-[(Difluoromethyl)sulfonyl]pyridine 98%
1g
$ 310.00

Crysdot
2-((Difluoromethyl)sulfonyl)pyridine 95+%
5g
$ 362.00

Frontier Specialty Chemicals
Difluoromethyl 2-pyridyl sulfone 98%
500mg
$ 59.00

Sigma-Aldrich
Difluoromethyl 2-pyridyl sulfone 97% (HPLC)
1g
$ 101.00

Total 35 raw suppliers

Chemical Property of Pyridine, 2-[(difluoromethyl)sulfonyl]-

Chemical Property:

Melting Point:47.0 to 51.0 °C
Boiling Point:324.4±42.0 °C(Predicted)
PKA:-2.60±0.19(Predicted)
PSA：55.41000
Density:1.423±0.06 g/cm3(Predicted)
LogP:2.15870
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%, ^*data from raw suppliers

2-((Difluoromethyl)sulfonyl)pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 25-36
Safety Statements: 26-45-24/25

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-[(Difluoromethyl)sulfonyl]pyridine is a new novel gem-difluoroolefination reagent for both aldehydes and ketones. Reagent is used in the olefination of ketones and aldehydes to form gem-difluoro olefins under basic conditions. Product is also used as a crucial intermediate toward making 1,1-difluorinated alkyl chains for the alkylation of heterocycles.

Technology Process of Pyridine, 2-[(difluoromethyl)sulfonyl]-

There total 5 articles about Pyridine, 2-[(difluoromethyl)sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 2-((difluoromethyl)thio)pyridine

: 1219454-89-3
2-((difluoromethyl)sulfonyl)pyridine

Guidance literature:: With sodium periodate; ruthenium(III) chloride trihydrate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 12h; Inert atmosphere; Schlenk technique;
DOI:10.1002/anie.201510533

Reference yield: 30.0%

: ethyl 2-(pyridine-2-ylsulfonyl)acetate

: 1219454-89-3
2-((difluoromethyl)sulfonyl)pyridine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; water; Inert atmosphere;
DOI:10.1002/ejoc.201403175

Reference yield:

: 2637-34-5,73018-10-7
2-Sulfanylpyridine

: 1219454-89-3
2-((difluoromethyl)sulfonyl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / water; acetonitrile / 0.5 h / -30 °C

2: sodium periodate; rhodium(III) chloride hydrate / 14 h / 20 °C

With sodium periodate; rhodium(III) chloride hydrate; potassium hydroxide; In water; acetonitrile;
DOI:10.1002/anie.201300763