2-(1-methyl-1H-pyrazol-4-yl)ethan-1-amine

Base Information

• Chemical Name: 2-(1-methyl-1H-pyrazol-4-yl)ethan-1-amine
• CAS No.: 796845-58-4
• Molecular Formula: C₆H₁₁N₃
• Molecular Weight: 125.173
• Hs Code.: 2933199090
• Mol file: 796845-58-4.mol

Synonyms:2-(1-methyl-1H-pyrazol-4-yl)ethanamine(SALTDATA: FREE);

Chemical Property of 2-(1-methyl-1H-pyrazol-4-yl)ethan-1-amine

Chemical Property:

• Boiling Point: 233.6±15.0℃ (760 Torr)
• Flash Point: 95.1±20.4℃
• PSA: 43.84000
• Density: 1.11±0.1 g/cm3 (20 ºC 760 Torr)
• LogP: 0.62160

Purity/Quality:

98%min ^*data from raw suppliers

2-(1-Methyl-1H-pyrazol-4-yl)ethanamine(~90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1-methyl-1H-pyrazol-4-yl)ethan-1-amine

There total 6 articles about 2-(1-methyl-1H-pyrazol-4-yl)ethan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 2-(1-methyl-1H-pyrazol-4-yl)ethylcarbamate → 2-(1-methyl-1H-pyrazol-4-yl)ethanamine (796845-58-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1h;

Reference yield:

C14H13N3O2 → 2-(1-methyl-1H-pyrazol-4-yl)ethanamine (796845-58-4)

Guidance literature:

With hydrogenchloride; at 110 ℃; for 16h;

Reference yield:

3-(1-methylpyrazol-4-yl)propanoic acid (796845-56-2) → 2-(1-methyl-1H-pyrazol-4-yl)ethanamine (796845-58-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 8 h / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

With diphenyl phosphoryl azide; hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; toluene;

upstream raw materials:

3-(1-methylpyrazol-4-yl)propanoic acid

2-(1H-pyrazol-4-yl)ethan-1-ol

4-(2-chloroethyl)-1H-pyrazole

N-[2-(1H-pyrazol-4-yl)-ethyl]-phthalimide

Downstream raw materials:

4-(4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-imidazol-5-yl)benzonitrile

Refernces

• 1、 -. "CEPHEM COMPOUNDS". Page 28. . Retrieved 2010/02/09.