5-Iodo-3-(trifluoromethyl)-2-pyridinamine

Base Information

• Chemical Name: 5-Iodo-3-(trifluoromethyl)-2-pyridinamine
• CAS No.: 911112-05-5
• Molecular Formula: C₆H₄F₃IN₂
• Molecular Weight: 288.011
• Mol file: 911112-05-5.mol

Synonyms:5-iodo-3-(trifluoromethyl)pyridin-2-amine;

Chemical Property of 5-Iodo-3-(trifluoromethyl)-2-pyridinamine

Chemical Property:

• Boiling Point: 279 oC
• PKA: 2.19±0.49(Predicted)
• Flash Point: 123 oC
• PSA: 38.91000
• Density: 2.049
• LogP: 2.86840
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

5-Iodo-3-(trifluoromethyl)pyridin-2-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Iodo-3-(trifluoromethyl)-2-pyridinamine

There total 3 articles about 5-Iodo-3-(trifluoromethyl)-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-bromo-3-(trifluoromethyl)pyridin-2-amine (79456-34-1) → 5-iodo-3-(trifluoromethyl)pyridin-2-amine (911112-05-5)

Guidance literature:

With potassium iodide; copper(l) iodide; N,N`-dimethylethylenediamine; In butan-1-ol; for 18h; Heating / reflux;

Reference yield: 89.0%

2-amino-3-trifluoromethylpyridine (183610-70-0) → 5-iodo-3-(trifluoromethyl)pyridin-2-amine (911112-05-5)

Guidance literature:

With N-iodo-succinimide; acetic acid; at 0 - 20 ℃; for 90h;

Reference yield: 76.0%

→ 5-iodo-3-(trifluoromethyl)pyridin-2-amine (911112-05-5)

Guidance literature:

upstream raw materials:

5-bromo-3-(trifluoromethyl)pyridin-2-amine

2-amino-3-trifluoromethylpyridine

Refernces

• 1、 -. "5-ALKYNYL-PYRIMIDINES". Page/Page column 9. . Retrieved 2012/02/06.
• 2、 -. "5-ALKYNYL-PYRIMIDINES". Page/Page column 9-10; 12-13. . Retrieved 2010/04/03.