3-Amino-7-hydroxy-2H-chromen-2-one

Base Information

• Chemical Name: 3-Amino-7-hydroxy-2H-chromen-2-one
• CAS No.: 79418-41-0
• Molecular Formula: C9H7NO3
• Molecular Weight: 177.159
• Hs Code.: 2932209090
• Mol file: 79418-41-0.mol

Synonyms:3-amino-7-hydroxychromen-2-one;

Chemical Property of 3-Amino-7-hydroxy-2H-chromen-2-one

Chemical Property:

• Melting Point: >260 oC
• PSA: 76.46000
• Density: 1.463±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 1.66200
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99.3% ^*data from raw suppliers

3-Amino-7-hydroxy-2H-chromen-2-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-7-hydroxy-2H-chromen-2-one

There total 16 articles about 3-Amino-7-hydroxy-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(2-oxo-7-hydroxy-2H-chromen-3-yl)pyridinium chloride (1616370-98-9) → 3-amino-7-hydroxy-2H-chromen-2-one (79418-41-0)

Guidance literature:

With 1-methyl-piperazine; In water; acetone; for 9h; Reflux;

DOI:10.1016/j.tet.2014.05.074

Reference yield: 96.0%

(7-hydroxy-2-oxo-2H-chromen-3-yl)carbamic acid tert-butyl ester (946833-00-7) → 3-amino-7-hydroxy-2H-chromen-2-one (79418-41-0)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2007.05.088

Reference yield: 92.0%

3-amino-7-(benzyloxy)-2H-chromen-2-one (1573010-11-3) → 3-amino-7-hydroxy-2H-chromen-2-one (79418-41-0)

Guidance literature:

3-amino-7-(benzyloxy)-2H-chromen-2-one; With hydrogenchloride; In methanol; Inert atmosphere; Cooling with ice;

With 5%-palladium/activated carbon; hydrogen; In methanol; under 760.051 Torr;

DOI:10.1007/s00044-014-0942-z

upstream raw materials:

(7-hydroxy-2-oxo-2H-chromen-3-yl)carbamic acid tert-butyl ester

3-acetamido-2-oxo-2H-chromen-7-yl acetate

2,4-Dihydroxybenzaldehyde

3-benzoylamino-7-hydroxy-2H-1-benzopyran-2-one

Downstream raw materials:

3-azido-7-hydroxycoumarin

(E)-3-((2,5-dimethoxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one

Refernces

• 1、 Tian, Xue,Kumawat, Lokesh K.,Bull, Steven D.,Elmes, Robert B.P.,Wu, Luling,James, Tony D.. "Coumarin-based fluorescent probe for the detection of glutathione and nitroreductase". . . Retrieved 2021.
• 2、 Pan, Zhixiu,Xu, Zhenxiang,Chen, Jie,Hu, Luping,Li, Hongqi,Zhang, Xin,Gao, Xucheng,Wang, Mengxuan,Zhang, Jian. "Coumarin Thiourea-Based Fluorescent Turn-on Hg2+ Probe That Can Be Utilized in a Broad pH Range 1–11". . p. 505 - 514. Retrieved 2020.
• 3、 Tong, Hongjuan,Zhao, Jianhong,Li, Xiangmin,Zhang, Yajun,Ma, Shengnan,Lou, Kaiyan,Wang, Wei. "Orchestration of dual cyclization processes and dual quenching mechanisms for enhanced selectivity and drastic fluorescence turn-on detection of cysteine". . p. 3583 - 3586. Retrieved 2017.
• 4、 Hirano, Tomoya,Noji, Yuki,Shiraishi, Takuya,Ishigami-Yuasa, Mari,Kagechika, Hiroyuki. "Development of an ‘OFF-ON-OFF’ fluorescent pH sensor suitable for the study of intracellular pH". . p. 4925 - 4930. Retrieved 2016.
• 5、 Fu, Zhen-Hai,Qin, Jing-Can,Wang, Min,Zhang, Zhi-Hong. "Design and synthesis of a solvent-dependent fluorescent probe for dual selective detection of Mg2+ ion and Zn2+ ion". . . Retrieved 2020/10/20.