5-fluoro-6-hydroxynicotinic acid

Base Information

Chemical Name:5-fluoro-6-hydroxynicotinic acid
CAS No.:1526-16-5
Molecular Formula:C₆H₄FNO₃
Molecular Weight:157.101
Hs Code.:
Mol file:1526-16-5.mol

Synonyms:5-fluoro-6-hydroxynicotinic acid

Suppliers and Price of 5-fluoro-6-hydroxynicotinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alichem
3-Fluoro-2-hydroxy-5-pyridinecarboxylicacid
1g
$ 1696.80

Alichem
3-Fluoro-2-hydroxy-5-pyridinecarboxylicacid
500mg
$ 989.80

Alichem
3-Fluoro-2-hydroxy-5-pyridinecarboxylicacid
250mg
$ 707.20

Total 9 raw suppliers

Chemical Property of 5-fluoro-6-hydroxynicotinic acid

Chemical Property:

Boiling Point:294.8±40.0 °C(Predicted)
PKA:3.36±0.50(Predicted)
PSA：70.42000
Density:1.56±0.1 g/cm3(Predicted)
LogP:0.62450

Purity/Quality:

97% ^*data from raw suppliers

3-Fluoro-2-hydroxy-5-pyridinecarboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 5-Fluoro-6-hydroxypyridine-3-carboxylic acid is a building block of Favipiravir (F103350). Favipiravir is used for the treatment of advanced Ebola virus infection in a small animal models.

Technology Process of 5-fluoro-6-hydroxynicotinic acid

There total 3 articles about 5-fluoro-6-hydroxynicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 5-fluoro-6-oxo-1,6-dihydropyridine-3-carboxylate

: 1526-16-5
5-fluoro-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Guidance literature:: methyl 5-fluoro-6-oxo-1,6-dihydropyridine-3-carboxylate; With water; sodium hydroxide; at 20 ℃; for 17h;

With hydrogenchloride; water; pH=3;
DOI:10.1016/j.bmc.2009.05.069