(R)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine Hydrochloride

Base Information

• Chemical Name: (R)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine Hydrochloride
• CAS No.: 93601-85-5
• Molecular Formula: C₁₄H₂₁NO*ClH
• Molecular Weight: 255.788
• Mol file: 93601-85-5.mol

Synonyms:(2R)-5-methoxy-2-propylaminotetralin hydrochloride;(R)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine Hydrochloride;(R)-2-(N-propylamino)-5-methoxytetralin hydrochloride;(R)-5-Methoxy-N-propyl-2-Aminotetralin Hydrochloride;(R)-5-methoxy-2-(N-n-propylamino)tetralin hydrochloride;(R)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride;(R)-(+)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride;

Chemical Property of (R)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine Hydrochloride

Chemical Property:

• PSA: 21.26000
• LogP: 3.74500

Purity/Quality:

97% ^*data from raw suppliers

(R)-5-Methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the production of antipsychotic agents and antiparkinson medications.

Technology Process of (R)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine Hydrochloride

There total 1 articles about (R)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H14ClO4P*C14H21NO → (R)-(+)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride (93601-85-5)

Guidance literature:

C₁₁H₁₄ClO₄P*C₁₄H₂₁NO; With water; sodium hydroxide; at 20 ℃; for 2h;

With hydrogenchloride;

DOI:10.1016/j.bmc.2010.06.025

Reference yield:

(R)-(+)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride (93601-85-5) → (R)-5-hydroxy-2-(di-n-propylamino)tetralin (69367-51-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 5percent aq. NaOH / CH₂Cl₂ / 0.5 h

2: LiAlH₄ / diethyl ether

3: BBr₃ / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; boron tribromide; In diethyl ether; dichloromethane;

DOI:10.1021/jm00380a012

Downstream raw materials:

(R)-5-hydroxy-2-(di-n-propylamino)tetralin

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