(R)-1-(4-Pyridinyl)ethylaMine 2HCl

Base Information

• Chemical Name: (R)-1-(4-Pyridinyl)ethylaMine 2HCl
• CAS No.: 45682-36-8
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• Mol file: 45682-36-8.mol

Synonyms:(R)-1-(4-Pyridinyl)ethylaMine 2HCl;(R)-1-(4-Pyridyl)ethylaMine;(aR)-a-Methyl-4-PyridineMethanaMine;(R)-1-(4-Pyridyl)ethylaMine 2HCl

Chemical Property of (R)-1-(4-Pyridinyl)ethylaMine 2HCl

Chemical Property:

• Boiling Point: 221.1±15.0 °C(Predicted)
• PKA: 8.28±0.29(Predicted)
• PSA: 38.91000
• Density: 1.018±0.06 g/cm3(Predicted)
• LogP: 1.80160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

(1R)-1-Pyridin-4-ylethanamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-(4-Pyridinyl)ethylaMine 2HCl

There total 7 articles about (R)-1-(4-Pyridinyl)ethylaMine 2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-[(1R)-1-azidoethyl]pyridine (603999-02-6) → (R)-1-(pyridin-4-yl)ethan-1-amine (45682-36-8)

Guidance literature:

With hydrogen; 5% Pd-CaCO3; In ethanol; for 2h; under 2327.23 Torr;

Reference yield:

methyl (4-pyridyl) ketone (1122-54-9) + bishydrochloride salt of cis-1,4-diamino-but-2-ene (87227-77-8,99240-70-7,114118-70-6,119874-79-2) → (R)-1-(pyridin-4-yl)ethan-1-amine (45682-36-8) + pyrrole (109-97-7,30604-81-0)

Guidance literature:

With transaminase ATA-033; In aq. phosphate buffer; dimethyl sulfoxide; at 30 ℃; for 48h; pH=7.5; Enzymatic reaction;

DOI:10.1002/adsc.201501066

Reference yield:

methyl (4-pyridyl) ketone (1122-54-9) → (R)-1-(pyridin-4-yl)ethan-1-amine (45682-36-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / Ti(OEt)4 / CH₂Cl₂ / 40 h / 40 °C

2: 90 percent / DIBAL / tetrahydrofuran / 6 h / -78 °C

3: aq. HCl / methanol / 20 °C

With hydrogenchloride; titanium(IV) tetraethanolate; diisobutylaluminium hydride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.tetasy.2006.11.026

upstream raw materials:

(R_S,R)-N-[1-(pyridin-4-yl)ethyl]-2-methylpropane-2-sulfinamide

(R_S)-N-[1-(pyridin-4-yl)ethylidene]-2-methylpropane-2-sulfinamide

methyl (4-pyridyl) ketone

4-[(1R)-1-azidoethyl]pyridine

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