OSI-420

Base Information

• Chemical Name: OSI-420
• CAS No.: 183320-51-6
• Molecular Formula: C21H21N3O4 · HCl or C1513C6H21N3O4 · HCl
• Molecular Weight: 421.83
• Mol file: 183320-51-6.mol

Synonyms:2-[[4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]ethanol hydrochloride;Ethanol, 2-[[4-[(3-ethynylphenyl)aMino]-7-(2-Methoxyethoxy)-6-quinazolinyl]oxy]-, hydrochloride;OSI-420 (DesMethyl Erlotinib,CP-473420)

Chemical Property of OSI-420

Chemical Property:

• PSA: 85.73000
• LogP: 3.62600

Purity/Quality:

98%,99%, ^*data from raw suppliers

OSI420 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells. OSI 420 can be used in biological study of effects of cytochrome P 450 3A on pharmacokinetic interaction between erlotinib and docetaxel in rats.