Chemical Property of Givinostat hydrochloride monohydrate
Chemical Property:
- PSA：100.13000
- LogP:5.75090
- Storage Temp.:-20°C
- Solubility.:≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥2.9 mg/mL in H2O with gentle warming and ultrasonic
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:9
- Exact Mass:475.1873988
- Heavy Atom Count:33
- Complexity:575
- Purity/Quality:
-
99%, *data from raw suppliers
GivinostatHydrochlorideHydrate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.Cl
- Recent ClinicalTrials:Effect of ITF2357 on Mucosal Healing in Patients With Moderate-to-severe Active Crohn's Disease
- Recent EU Clinical Trials:A randomised, double-blind, placebo-controlled study to evaluate the micro-macroscopic effects on muscles, the safety and tolerability, and the efficacy of
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Uses
Givinostat Hydrochloride Hydrate is a potent inhibitor of HDAC with IC50?of 7.5-16 nM. It is used in the treatment of muscular dystrophy. Givinostat hydrochloride hydrate has been used as a histone deacetylase inhibitor to test its effect on the human immunodeficiency virus reactivation in CD4+ T-cell model.
