Sapitinib

Base Information

Chemical Name:Sapitinib
CAS No.:848942-61-0
Molecular Formula:C₂₃H₂₅ClFN₅O₃
Molecular Weight:473.935
Hs Code.:
European Community (EC) Number:642-427-0,935-731-2
UNII:3499328002
ChEMBL ID:CHEMBL2408045
DSSTox Substance ID:DTXSID50233942
Metabolomics Workbench ID:153217
NCI Thesaurus Code:C77887
Pharos Ligand ID:26P3748YRDBK
Wikidata:Q27088689
Mol file:848942-61-0.mol

Synonyms:AZD 8931;AZD-8931;AZD8931;sapitinib

Suppliers and Price of Sapitinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Sapitinib(AZD8931) 98+%
100mg
$ 693.00

Crysdot
Sapitinib(AZD8931) 98+%
5mg
$ 66.00

Crysdot
Sapitinib(AZD8931) 98+%
10mg
$ 123.00

Crysdot
Sapitinib(AZD8931) 98+%
50mg
$ 441.00

ChemScene
Sapitinib 99.99%
50mg
$ 190.00

ChemScene
Sapitinib 99.99%
100mg
$ 290.00

ChemScene
Sapitinib 99.99%
10mg
$ 90.00

ChemScene
Sapitinib 99.99%
5mg
$ 60.00

Chemenu
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quinazoline 98%
100mg
$ 762.00

Cayman Chemical
AZD 8931 ≥98%
1mg
$ 39.00

Total 37 raw suppliers

Chemical Property of Sapitinib

Chemical Property:

Boiling Point:632.8±55.0 °C(Predicted)
PKA:16.17±0.46(Predicted)
PSA：92.10000
Density:1.339
LogP:4.61490
Solubility.:≥23.7 mg/mL in DMSO; insoluble in H2O; ≥57.8 mg/mL in EtOH with gentle warming
XLogP3:4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:473.1629955
Heavy Atom Count:33
Complexity:641

Purity/Quality:

99%, ^*data from raw suppliers

Sapitinib(AZD8931) 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC
Recent ClinicalTrials:SAFIR02_Lung - Efficacy of Targeted Drugs Guided by Genomic Profiles in Metastatic NSCLC Patients
Recent EU Clinical Trials:Evaluation of the efficacy of high throughput genome analysis as a therapeutic decision tool for patients with metastatic non small cell lung cancer

Technology Process of Sapitinib

There total 27 articles about Sapitinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1196531-38-0
2-[4-(4-amino-5-cyano-2-methoxy-phenoxy)-1-piperidyl]-N-methylacetamide

: 1252041-51-2
N,N'-bis(3-chloro-2-fluoro-phenyl)formamidine

: 848942-61-0
Sapitinib

Guidance literature:: 2-[4-(4-amino-5-cyano-2-methoxy-phenoxy)-1-piperidyl]-N-methylacetamide; N,N'-bis(3-chloro-2-fluoro-phenyl)formamidine; With acetic acid; In 2-methyltetrahydrofuran; at 80 - 92 ℃; for 6h;

With sodium hydroxide; In 2-methyltetrahydrofuran; water; at 55 - 63 ℃; Product distribution / selectivity;

Reference yield: 73.0%

: 1196531-38-0
2-[4-(4-amino-5-cyano-2-methoxy-phenoxy)-1-piperidyl]-N-methylacetamide

: 1252041-52-3
N'-(3-chloro-2-fluoro-phenyl)-N,N-dimethyl-formamidine

: 848942-61-0
Sapitinib

Guidance literature:: 2-[4-(4-amino-5-cyano-2-methoxy-phenoxy)-1-piperidyl]-N-methylacetamide; N'-(3-chloro-2-fluoro-phenyl)-N,N-dimethyl-formamidine; With acetic acid; In 2-methyltetrahydrofuran; at 90 ℃; for 14h;

With sodium hydroxide; In 2-methyltetrahydrofuran; water; at 55 - 63 ℃;