3-AMino-3-(hydroxyMethyl)-1-(4-octylphenyl)-1,4-butanediol

Base Information

Chemical Name:3-AMino-3-(hydroxyMethyl)-1-(4-octylphenyl)-1,4-butanediol
CAS No.:162361-49-1
Molecular Formula:C19H33NO3
Molecular Weight:323.470
Hs Code.:
Mol file:162361-49-1.mol

Synonyms:1-Hydroxy Fingolimod;3-amino-3-(hydroxymethyl)-1-(4-octylphenyl)butane-1,4-diol;3-AMino-3-(hydroxyMethyl)-1-(4-octylphenyl)-1,4-butanediol;1,4-Butanediol, 3-amino-3-(hydroxymethyl)-1-(4-octylphenyl)-;3-Amino-3-(hydroxymethyl)-1-(4-octylphenyl)butane-1,4-diol (1-Hydroxyfingolimod)

Suppliers and Price of 3-AMino-3-(hydroxyMethyl)-1-(4-octylphenyl)-1,4-butanediol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-HydroxyFingolimod
25mg
$ 1030.00

Total 12 raw suppliers

Chemical Property of 3-AMino-3-(hydroxyMethyl)-1-(4-octylphenyl)-1,4-butanediol

Chemical Property:

Vapor Pressure:0.0±1.4 mmHg at 25°C
Boiling Point:514.9±50.0 °C at 760 mmHg
Flash Point:265.2±30.1 °C
Density:1.1±0.1 g/cm3
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

98%Min ^*data from raw suppliers

1-HydroxyFingolimod ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 1-Hydroxy Fingolimod, is an impurity of Fingolimod (F805000), an immunomodulating drug, mostly used for treating multiple sclerosis (MS). Fingolimod is also a sphingosine-1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes, preventing them from contributing to an autoimmune reaction.

Technology Process of 3-AMino-3-(hydroxyMethyl)-1-(4-octylphenyl)-1,4-butanediol

There total 5 articles about 3-AMino-3-(hydroxyMethyl)-1-(4-octylphenyl)-1,4-butanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: N-[1,4-dihydroxy-2-(hydroxymethyl)-4-(4-octylphenyl)butan-2-yl]acetamide

: 162361-49-1
3-amino-3-(hydroxymethyl)-1-(4-octylphenyl)butane-1,4-diol

Guidance literature:: With sodium hydroxide; In methanol; for 6h; Reflux;

Reference yield:

: 2-acetamido-4-acetoxy-2-acetoxymethyl4-(4-octylphenyl)butyl acetate

: 162361-49-1
3-amino-3-(hydroxymethyl)-1-(4-octylphenyl)butane-1,4-diol

Guidance literature:: With sodium hydroxide; In methanol; water;

Reference yield:

: 2189-60-8
Octylbenzene

: 162361-49-1
3-amino-3-(hydroxymethyl)-1-(4-octylphenyl)butane-1,4-diol

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / -10 - 20 °C

2: caesium carbonate / acetonitrile / 4 h / Reflux

3: lithium chloride; ethanol; sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C

4: sodium hydroxide / methanol / 6 h / Reflux

With aluminum (III) chloride; sodium tetrahydroborate; ethanol; caesium carbonate; lithium chloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;