3H-SPIRO[ISOBENZOFURAN-1,3'-PIPERIDIN]-3-ONE

Base Information

• Chemical Name: 3H-SPIRO[ISOBENZOFURAN-1,3'-PIPERIDIN]-3-ONE
• CAS No.: 189321-67-3
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.241
• Hs Code.: 2934999090
• Mol file: 189321-67-3.mol

Synonyms:3H-SPIRO[ISOBENZOFURAN-1,3-PIPERIDIN]-3-ONE;Spiro[isobenzofuran-1(3H),3-piperidin]-3-one;3H-spiro[2-benzofuran-1,3-piperidine]-3-one

Chemical Property of 3H-SPIRO[ISOBENZOFURAN-1,3'-PIPERIDIN]-3-ONE

Chemical Property:

• Boiling Point: 411oC at 760 mmHg
• Flash Point: 202.3oC
• PSA: 38.33000
• Density: 1.25g/cm3
• LogP: 1.76450

Purity/Quality:

98%min ^*data from raw suppliers

3H-Spiro[isobenzofuran-1,3'-piperidin]-3-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3H-SPIRO[ISOBENZOFURAN-1,3'-PIPERIDIN]-3-ONE

There total 2 articles about 3H-SPIRO[ISOBENZOFURAN-1,3'-PIPERIDIN]-3-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1'-benzyl-spiro[isobenzofuran-1,3'-piperidin]-3-one; hydrochloride (54596-16-6) → spiro[isobenzofuran-1,3'-piperidin]-3-one (189321-67-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 3h; under 2280 Torr;

DOI:10.1021/jo00898a010

Reference yield:

1'-benzyl-spiro[isobenzofuran-1,3'-piperidin]-3-one (56658-24-3) → spiro[isobenzofuran-1,3'-piperidin]-3-one (189321-67-3)

Guidance literature:

Reference yield:

spiro[isobenzofuran-1,3'-piperidin]-3-one (189321-67-3) + α-chloro-p-fluorobutyrophenone ethylene ketal (56658-08-3) → 1,3-dihydro-1'-[3-(4-fluorobenzoyl)propyl]spiro[isobenzofuran-1,3'-piperidine]-3-one

Guidance literature:

upstream raw materials:

1'-benzyl-spiro[isobenzofuran-1,3'-piperidin]-3-one; hydrochloride

1'-benzyl-spiro[isobenzofuran-1,3'-piperidin]-3-one

Refernces

• 1、 Marxer,Rodriguez,McKenna,Tsai. "Spiro piperidines. I. Synthesis of spiro[isobenzofuran 1(3 H),4' piperidines] and spiro[isobenzofuran 1(3 H),3' piperidines]". . p. 1427 - 1433. Retrieved 2007/10/05.