6-Bromo-4-nitro-1H-indazole

Base Information

• Chemical Name: 6-Bromo-4-nitro-1H-indazole
• CAS No.: 885518-46-7
• Molecular Formula: C7H4BrN3O2
• Molecular Weight: 242.032
• Hs Code.: 2933990090
• Mol file: 885518-46-7.mol

Synonyms:6-bromo-4-nitro-indazole; 1H-Indazole,6-bromo-4-nitro

Chemical Property of 6-Bromo-4-nitro-1H-indazole

Chemical Property:

• Boiling Point: 420.8±25.0 °C(Predicted)
• PKA: 9.86±0.40(Predicted)
• PSA: 74.50000
• Density: 1.965
• LogP: 2.75680
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-4-nitro-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Bromo-4-nitro-1H-indazole is a reagent in the preparation of 1,2,4-triazine-6-carboxamide derivatives having acetamide group as Syk kinase inhibitors for the treatment of cancer, allergy, or autoimmune diseases.

Technology Process of 6-Bromo-4-nitro-1H-indazole

There total 4 articles about 6-Bromo-4-nitro-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-bromo-2-methyl-3-nitroaniline (864550-40-3) → 6-bromo-4-nitro-1H-indazole (885518-46-7)

Guidance literature:

With acetic acid; sodium nitrite; at 20 ℃; for 12h;

Reference yield: 62.0%

→ 6-bromo-4-nitro-1H-indazole (885518-46-7)

Guidance literature:

With acetic acid; sodium nitrite; In water; at 0 - 20 ℃; for 6h;

Reference yield:

2,6-dinitrotoluene (606-20-2) → 6-bromo-4-nitro-1H-indazole (885518-46-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 15 h / 20 °C

2: hydrogenchloride; iron / methanol; 1,4-dioxane; water / 12 h / 80 °C

3: acetic acid; sodium nitrite / 12 h / 20 °C

With hydrogenchloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; iron; acetic acid; sodium nitrite; In 1,4-dioxane; methanol; water;

upstream raw materials:

2,6-dinitrotoluene

5-bromo-2-methyl-1,3-dinitrobenzene

5-bromo-2-methyl-3-nitroaniline