(S)-4-FLUORO-INDAN-1-YLAMINE

Base Information

• Chemical Name: (S)-4-FLUORO-INDAN-1-YLAMINE
• CAS No.: 946053-90-3
• Molecular Formula: C₉H₁₀FN
• Molecular Weight: 151.184
• Hs Code.: 2921499090
• Mol file: 946053-90-3.mol

Synonyms:(S)-4-FLUORO-INDAN-1-YLAMINE;(s)-4-fluoro-indan-1-ylaMine-hcl;(S)-4-Fluoro-2,3-dihydro-1H-inden-1-aMine;(1S)-4-fluoro-2,3-dihydro-1H-inden-1-aMine

Chemical Property of (S)-4-FLUORO-INDAN-1-YLAMINE

Chemical Property:

• Vapor Pressure: 0.139mmHg at 25°C
• Boiling Point: 216.584°C at 760 mmHg
• PKA: 8.85±0.20(Predicted)
• Flash Point: 94.505°C
• PSA: 26.02000
• Density: 1.16g/cm³
• LogP: 2.47200
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

(S)-4-Fluoro-2,3-dihydro-1H-inden-1-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-4-FLUORO-INDAN-1-YLAMINE

There total 4 articles about (S)-4-FLUORO-INDAN-1-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-Fluorindanon-1-oxim (73045-31-5) → 1-fluoro-benzocyclopentyl-5-amine (148960-34-3,148960-38-7,1637635-81-4,946053-90-3)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 16h;

Reference yield: 50.0%

→ 1-fluoro-benzocyclopentyl-5-amine (148960-34-3,148960-38-7,1637635-81-4,946053-90-3)

Guidance literature:

Reference yield:

1-fluoro-benzocyclopentyl-5-amine (148960-34-3,148960-38-7,1637635-81-4,946053-90-3) → 4-fluoro-1R-aminoindane (1637635-81-4,946053-90-3) + C9H8FN

Guidance literature:

With borane-ammonia complex; monoamine oxidase variant D₉ from Aspergillus niger; In dimethyl sulfoxide; at 37 ℃; for 24h; pH=9; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.bmc.2017.07.023

upstream raw materials:

4-fluoro-1-indanone

4-Fluorindanon-1-oxim

1-fluoro-benzocyclopentyl-5-amine

Refernces

• 1、 Herter, Susanne,Medina, Florian,Wagschal, Simon,Benha?m, Cyril,Leipold, Friedemann,Turner, Nicholas J.. "Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines". . p. 1338 - 1346. Retrieved 2017/10/06.
• 2、 -. "THERAPEUTIC FLUOROETHYLCYANO GUANIDINES". Page/Page column 14. . Retrieved 2008/12/04.