TpTp

Base Information

• Chemical Name: TpTp
• CAS No.: 2476-56-4
• Molecular Formula: C₂₀H₂₈N₄O₁₅P₂
• Molecular Weight: 626.408
• Mol file: 2476-56-4.mol

Synonyms:Thymidine,3'-O-phosphorylthymidylyl-(5'®3')- (7CI,8CI); Dithymidylic acid

Chemical Property of TpTp

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 49.33000
• Density: 1.75g/cm³
• LogP: 2.37730

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TpTp

There total 25 articles about TpTp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidylyl(3'-P-(2-(p-nitrophenyl)ethyl)>-5')thymidine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate) (85363-85-5) → 5'-d(TpTp)-3' (2476-56-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; for 24h; Ambient temperature;

DOI:10.1002/hlca.19870700508

Reference yield: 91.0%

TLTrTp(SPh)Tp(SPh)2 (96255-89-9) → 5'-d(TpTp)-3' (2476-56-4)

Guidance literature:

With pyridine; ammonium hydroxide; hydrogen sulfide; silver(I) acetate; 1)50 deg C 9h, 2)0 deg C, 3) 50 ded C 4h;;

DOI:10.1246/bcsj.58.336

Reference yield:

dibenzyl phosphochloridate (538-37-4) → 5'-d(TpTp)-3' (2476-56-4)

Guidance literature:

With pyridine; Behandlung mit NaOH in wss. Dioxan und anschliessende Hydrierung an Palladium/BaSO₄;

DOI:10.1021/ja01556a016

upstream raw materials:

5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidylyl(3'-P-(2-(p-nitrophenyl)ethyl)>-5')thymidine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate)

C₄₆H₅₃N₆O₁₄P₂S₄^(1-)

TLTrTp(SPh)Tp(SPh)2

dibenzyl phosphochloridate