Fondaparinux sodiuM interMediate A

Base Information

• Chemical Name: Fondaparinux sodiuM interMediate A
• CAS No.: 114870-02-9
• Molecular Formula: C31H53N3O40S5.7Na
• Molecular Weight: 1428.9863
• Mol file: 114870-02-9.mol

Synonyms:α-D-Glucopyranoside, methyl O-2-amino-2-deoxy-6-O-sulfo-α-D-glucopyranosyl-(1→4)-O-β-D-glucopyranuronosyl-(1→4)-O-2-amino-2-deoxy-3,6-di-O-sulfo-α-D-glucopyranosyl-(1→4)-O-2-O-sulfo-α-L-idopyranuronosyl-(1→4)-2-amino-2-deoxy-, 6-(hydrogen sulfate), heptasodium salt (9CI)

Chemical Property of Fondaparinux sodiuM interMediate A

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Fondaparinux sodiuM interMediate A

There total 7 articles about Fondaparinux sodiuM interMediate A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.67%

methyl O-2-azido-2-deoxy-3,4-di-O-benzyl-6-O-sulfo-α-D-glucopyranosyl-(1-4)-O-2,3-O-dibenzyl-β-D-glucopyranosyluronosyl-(1-4)-O-2-azido-2-deoxy-3,6-di-O-sulfo-α-D-glucopyranosyl-(1-4)-O-3-O-benzyl-2-O-sulfo-α-L-idopyranuronosyl-(1-4)-2-azido-2-deoxy-6-O-sulfo-α-D-glucopyranoside heptasodium salt → methyl (2-azido-2-deoxy-6-O-sulfonato-α-D-glucopyranosyl)-(1→4)-(β-D-glucopyranosyluronate)-(1→4)-(2-amino-2-deoxy-3,6-di-O-sulfonato-α-D-glucopyranosyl)-(1→4)-(2-O-sulfonato-α-L-idopyranosyluronate)-(1→4)-2-amino-2-deoxy-6-O-sulfonato-α-D-glucopyranoside sodium salt (114870-02-9,119254-84-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water; at 20 ℃; under 5171.62 Torr; Product distribution / selectivity;

Reference yield: 95.6%

5Na(1+)*C81H86N7O42S5(5-) → methyl (2-azido-2-deoxy-6-O-sulfonato-α-D-glucopyranosyl)-(1→4)-(β-D-glucopyranosyluronate)-(1→4)-(2-amino-2-deoxy-3,6-di-O-sulfonato-α-D-glucopyranosyl)-(1→4)-(2-O-sulfonato-α-L-idopyranosyluronate)-(1→4)-2-amino-2-deoxy-6-O-sulfonato-α-D-glucopyranoside sodium salt (114870-02-9,119254-84-1)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; water; at 40 ℃; for 20h; under 4500.45 - 6000.6 Torr;

Reference yield: 80.0%

methyl [2-azido-3-O-(4-bromobenzyl)-2-deoxy-4-O-(2-naphthylmethyl)-6-O-sulfonato-α-D-glucopyranosyl]-(1→4)-(3-O-benzyl-β-D-glucopyranosyluronate)-(1→4)-(2-azido-2-deoxy-3,6-di-O-sulfonato-α-D-glucopyranosyl)-(1→4)-(3-O-benzyl-2-O-sulfonato-α-L-idopyranosyluronate)-(1→4)-2-azido-3-O-(4-bromobenzyl)-2-deoxy-6-O-sulfonato-α-D-glucopyranoside sodium salt → methyl (2-azido-2-deoxy-6-O-sulfonato-α-D-glucopyranosyl)-(1→4)-(β-D-glucopyranosyluronate)-(1→4)-(2-amino-2-deoxy-3,6-di-O-sulfonato-α-D-glucopyranosyl)-(1→4)-(2-O-sulfonato-α-L-idopyranosyluronate)-(1→4)-2-amino-2-deoxy-6-O-sulfonato-α-D-glucopyranoside sodium salt (114870-02-9,119254-84-1)

Guidance literature:

With 20% palladium hydroxide-activated charcoal; hydrogen; In aq. phosphate buffer; at 20 ℃; for 48h; pH=7;

DOI:10.1002/anie.201404154

Downstream raw materials:

fondaparinux

Refernces

• 1、 -. "New process method for preparing fondaparinux sodium". Paragraph 0049; 0050. . Retrieved 2018/07/15.
• 2、 -. "PROCESS FOR THE PRODUCTION OF FONDAPARINUX SODIUM". Paragraph 0103-0106. . Retrieved 2017/01/31.