N-HYDROXY-2-MORPHOLIN-4-YL-ACETAMIDINE

Base Information

• Chemical Name: N-HYDROXY-2-MORPHOLIN-4-YL-ACETAMIDINE
• CAS No.: 5815-63-4
• Molecular Formula: C6H13N3O2
• Molecular Weight: 159.188
• Hs Code.: 2934999090
• Mol file: 5815-63-4.mol

Synonyms:UKRORGSYN-BB BBV-086051;(1Z)-N'-hydroxy-2-(4-morpholinyl)ethanimidamide(SALTDATA: FREE);

Chemical Property of N-HYDROXY-2-MORPHOLIN-4-YL-ACETAMIDINE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 265.604°C at 760 mmHg
• Flash Point: 114.433°C
• PSA: 71.08000
• Density: 1.365g/cm³
• LogP: -0.29680

Purity/Quality:

97% ^*data from raw suppliers

2-(Morpholin-4-yl)acetamidoxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-HYDROXY-2-MORPHOLIN-4-YL-ACETAMIDINE

There total 2 articles about N-HYDROXY-2-MORPHOLIN-4-YL-ACETAMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-morpholinoacetonitrile (5807-02-3) → N-hydroxy-2-(4-morpholinyl)ethanimidamide (5815-63-4)

Guidance literature:

With hydrogenchloride; ethanol; hydroxylamine; sodium carbonate;

DOI:10.1021/jo01102a007

Reference yield:

→ N-hydroxy-2-(4-morpholinyl)ethanimidamide (5815-63-4)

Guidance literature:

entspr. Nitril, Hydroxylamin;

Reference yield: 82.0%

N-hydroxy-2-(4-morpholinyl)ethanimidamide (5815-63-4) + 3-((2-(cyclopropanecarboxamido)pyridin-4-yl)amino)-2-methoxybenzoic acid hydrochloride → (Z)-N-(4-((3-((((1-amino-2-morpholinoethylidene)amino)oxy)carbonyl)-2-methoxyphenyl)amino)pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

upstream raw materials:

4-morpholinoacetonitrile