CHEMPACIFIC 38182

Base Information

• Chemical Name: CHEMPACIFIC 38182
• CAS No.: 1620-78-6
• Molecular Formula: C7H6F3N
• Molecular Weight: 161.13
• Hs Code.: 2933399090
• Mol file: 1620-78-6.mol

Synonyms:CHEMPACIFIC 38182;3-METHYL-2-TRIFLUOROMETHYL-PYRIDINE

Chemical Property of CHEMPACIFIC 38182

Chemical Property:

• Vapor Pressure: 6.79mmHg at 25°C
• Boiling Point: 143.1°C at 760 mmHg
• PKA: 0.84±0.22(Predicted)
• Flash Point: 40.4°C
• PSA: 12.89000
• Density: 1.216g/cm³
• LogP: 2.40880
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-Methyl-2-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CHEMPACIFIC 38182

There total 6 articles about CHEMPACIFIC 38182 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-bromo-3-picoline (3430-17-9) + iodotrifluoromethane (2314-97-8,263005-66-9) → 3-methyl-2-(trifluoromethyl)pyridine (1620-78-6)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; copper; at 112 - 130 ℃; for 4h; autoclave;

DOI:10.1248/cpb.38.2446

Reference yield:

2-bromo-3-picoline (3430-17-9) + (1,10-phenanthroline)(trifluoromethyl)copper (I) → 3-methyl-2-(trifluoromethyl)pyridine (1620-78-6)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 8h; Sealed tube; Inert atmosphere;

DOI:10.1021/ol500422t

Reference yield:

2-bromo-3-picoline (3430-17-9) + trifluoromethylcopper(I) (77152-08-0) → 3-methyl-2-(trifluoromethyl)pyridine (1620-78-6)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In N,N-dimethyl-formamide; at 23 - 50 ℃; for 33h; Glovebox; Sealed tube;

DOI:10.1021/jo401423h

upstream raw materials:

2-bromo-3-picoline

iodotrifluoromethane

3-methylpyridin-2-ylamine

trifluoromethylcopper(I)

Downstream raw materials:

(2-(trifluoromethyl)pyridin-3-yl)methanol

2-(trifluoromethyl)-3-pyridinecarboxaldehyde

2-(trifluoromethyl)nicotinic acid

Refernces

• 1、 Mormino, Michael G.,Fier, Patrick S.,Hartwig, John F.. "Copper-mediated perfluoroalkylation of heteroaryl bromides with (phen)CuRF". . p. 1744 - 1747. Retrieved 2014/04/17.
• 2、 Ashimori,Ono,Uchida,Ohtaki,Fukaya,Watanabe,Yokoyama. "Novel 1,4-dihydropyridine calcium antagonists. I. Synthesis and hypotensive activity of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives". . p. 2446 - 2458. Retrieved 2007/10/02.