L-LYSINE-4,4,5,5-D4 HCL

Base Information

• Chemical Name: L-LYSINE-4,4,5,5-D4 HCL
• CAS No.: 284664-96-6
• Molecular Formula: C₆H₁₄N₂O₂*2ClH
• Molecular Weight: 225.064
• Mol file: 284664-96-6.mol

Synonyms:L-Lysine-4;L-Lysine-d4 HCl;BVHLGVCQOALMSV-UGJIAQRQSA-N;[2H4]-L-Lysine Hydrochloride

Chemical Property of L-LYSINE-4,4,5,5-D4 HCL

Chemical Property:

• PSA: 89.34000
• LogP: 1.72990

Purity/Quality:

99% ^*data from raw suppliers

L-Lysine-4,4,5,5-d4Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-Lysine-4,4,5,5-d4 Hydrochloride is a naturally occurring amino acid which is used in the labelling of human bone marrow mesenchymal stem cells for analysis. Labelled L-Lysine is a naturally occurring amino acid which is used in the labelling of human bone marrow mesenchymal stem cells for analysis.

Technology Process of L-LYSINE-4,4,5,5-D4 HCL

There total 6 articles about L-LYSINE-4,4,5,5-D4 HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl N2,N6-bis(tert-butoxycarbonyl)-4,4,5,5-d4-(S)-lysinate → 4,4,5,5-d4-(S)-lysine dihydrochloride (284664-88-6,284664-96-6)

Guidance literature:

methyl N²,N⁶-bis(tert-butoxycarbonyl)-4,4,5,5-d₄-(S)-lysinate; With lithium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃;

With hydrogenchloride; In ethyl acetate; for 4h;

DOI:10.1055/s-0037-1610221

Reference yield: 85.0%

N-benzoyl[3,3,4,4,5,5-2H6]lysine → [3,3,4,4,5,5-2H6]lysine dihydrochloride (284664-88-6,284664-96-6)

Guidance literature:

With hydrogenchloride; for 10h; Heating;

Reference yield:

C6H7(2)H6NO2 → [3,3,4,4,5,5-2H6]lysine dihydrochloride (284664-88-6,284664-96-6)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH / 1 h / Ambient temperature

2: 65 percent / PBr₃, Br₂ / 0.17 h / 100 °C

3: 66 percent / 28percent aq. NH₄OH / 0.5 h / Heating

4: 85 percent / aq. HCl / 10 h / Heating

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; bromine; phosphorus tribromide;

upstream raw materials:

[3,3,4,4,5,5-2H6]-ε-caprolactam

Refernces

• 1、 Tsuzuki, Hirohisa,Mashimo, Takuya,Mukumoto, Mamoru,Mataka, Shuntaro,Udagawa, Jun,Tashiro, Masashi. "Synthesis of - and Lysines". . p. 2346 - 2360. Retrieved 2007/10/03.