Technology Process of (2R,6R,11R)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-buten-1-yl)-2,6-methano-3-benzazocin-8-ol
There total 29 articles about (2R,6R,11R)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-buten-1-yl)-2,6-methano-3-benzazocin-8-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium thioethylate;
In
N,N-dimethyl-formamide;
at 130 ℃;
for 5h;
DOI:10.1021/ja0360539
- Guidance literature:
-
With
triethylamine;
In
1-methyl-pyrrolidin-2-one;
at 40 - 45 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: (η3-C3H5PdCl)2; (R,R)-bridged dihydroanthracene derivative ligand; Cs2CO3 / 1,2-dimethoxy-ethane / 0.25 h / 20 °C
1.2: 1,2-dimethoxy-ethane / 0.08 h / 20 °C
2.1: 98 percent / t-BuOK / tetrahydrofuran / 20 °C
3.1: 82 percent / NMO; aq. OsO4 / tetrahydrofuran / 5 h / 20 °C
4.1: 92 percent / aq. NaIO4 / tetrahydrofuran / 1 h / 20 °C
5.1: MgSO4 / tetrahydrofuran; methanol / 20 °C
5.2: 85 percent / NaBH4 / tetrahydrofuran; methanol / 1 h
6.1: 100 percent / iPr2NH; tetramethylenediamine; n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
7.1: 94 percent / NaSEt / dimethylformamide / 5 h / 130 °C
With
sodium periodate; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; bis(η3-allyl-μ-chloropalladium(II)); N,N,N,N,-tetramethylethylenediamine; (R,R)-bridged dihydroanthracene derivative ligand; potassium tert-butylate; magnesium sulfate; caesium carbonate; diisopropylamine; sodium thioethylate;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; N,N-dimethyl-formamide;
2.1: Wittig olefination;
DOI:10.1021/ja0360539
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