3-(2,6-Dichlorophenyl)-5-ethylisoxazole-4-carboxylic acid

Base Information

• Chemical Name: 3-(2,6-Dichlorophenyl)-5-ethylisoxazole-4-carboxylic acid
• CAS No.: 286435-86-7
• Molecular Formula: C12H9Cl2NO3
• Molecular Weight: 286.114
• DSSTox Substance ID: DTXSID00369402
• Wikidata: Q82156465
• Mol file: 286435-86-7.mol

Synonyms:286435-86-7;3-(2,6-dichlorophenyl)-5-ethylisoxazole-4-carboxylic acid;3-(2,6-dichlorophenyl)-5-ethyl-1,2-oxazole-4-carboxylic acid;4-Isoxazolecarboxylic acid, 3-(2,6-dichlorophenyl)-5-ethyl-;Maybridge1_005840;Oprea1_507920;SCHEMBL4007719;HMS558B10;DTXSID00369402;CCG-1726;AKOS013477304;FT-0715830;3-(2,6-DICHLOROPHENYL)-5-ETHYLISOXAZOLE-4-CARBOXYLICACID

Chemical Property of 3-(2,6-Dichlorophenyl)-5-ethylisoxazole-4-carboxylic acid

Chemical Property:

• PSA: 63.33000
• LogP: 3.90900
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 284.9959485
• Heavy Atom Count: 18
• Complexity: 306

Purity/Quality:

3-(2,6-DICHLOROPHENYL)-5-ETHYLISOXAZOLE-4-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)C(=O)O

Technology Process of 3-(2,6-Dichlorophenyl)-5-ethylisoxazole-4-carboxylic acid

There total 1 articles about 3-(2,6-Dichlorophenyl)-5-ethylisoxazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl propanoylacetate (4949-44-4) → 3-(2,6-dichloro-phenyl)-5-ethyl-isoxazole-4-carboxylic acid (286435-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOMe / methanol / 20 °C

2: aq. NaOH / methanol

With sodium hydroxide; sodium methylate; In methanol;

DOI:10.1016/j.bmcl.2004.06.060

Reference yield:

(2-chloro-6-fluorophenyl)methanol (56456-50-9) + 3-(2,6-dichloro-phenyl)-5-ethyl-isoxazole-4-carboxylic acid (286435-86-7) → (2-chloro-6-fluoro-phenyl)methyl N-(3-(2,6-dichloro-phenyl)-5-ethyl-1,2-oxazol-4-yl)-carbamate (1104461-28-0)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; at 180 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

N,N-diethylaniline (93-05-0) + 3-(2,6-dichloro-phenyl)-5-ethyl-isoxazole-4-carboxylic acid (286435-86-7) → 3-(2,6-dichlorophenyl)-N-[4-(diethylamino)phenyl]-5-ethylisoxazole-4-carboxamide

Guidance literature:

With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2004.06.060

upstream raw materials:

ethyl propanoylacetate

Downstream raw materials:

(2-chloro-6-fluoro-phenyl)methyl N-(3-(2,6-dichloro-phenyl)-5-ethyl-1,2-oxazol-4-yl)-carbamate