(2R,4S)-4-AMINO-1-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCl

Base Information

• Chemical Name: (2R,4S)-4-AMINO-1-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCl
• CAS No.: 489446-77-7
• Molecular Formula: C₁₄H₁₈N₂O₄*ClH
• Molecular Weight: 314.769
• Mol file: 489446-77-7.mol

Synonyms:1-O-benzyl 2-O-methyl (2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate,hydrochloride;

Chemical Property of (2R,4S)-4-AMINO-1-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCl

Chemical Property:

• PSA: 81.86000
• LogP: 2.33800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(2R,4S)-1-Benzyl2-methyl4-aminopyrrolidine-1,2-dicarboxylatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,4S)-4-AMINO-1-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCl

There total 2 articles about (2R,4S)-4-AMINO-1-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl 2-methyl (2S,4R)-4-(tert-butoxycarbonylamino)pyrrolidine-1,2-dicarboxylate (189215-90-5) → methyl (2S,4R)-4-amino-1-[benzyloxycarbonyl]pyrrolidine-2-carboxylate hydrochloride (1212395-57-7,489446-77-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

DOI:10.1016/S0960-894X(02)00467-5

Reference yield:

4S-N4(t-boc)-N1-(benzyloxycarbonyl)-D-proline methylester → (2R,4S)-4-Amino-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester; hydrochloride (1212395-57-7,489446-77-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

DOI:10.1016/S0960-894X(02)00467-5

upstream raw materials:

1-benzyl 2-methyl (2S,4R)-4-(tert-butoxycarbonylamino)pyrrolidine-1,2-dicarboxylate

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