(2S,4R)-1-BOC-2-hydroxyMethyl-4-aMino Pyrrolidine-HCl

Base Information

• Chemical Name: (2S,4R)-1-BOC-2-hydroxyMethyl-4-aMino Pyrrolidine-HCl
• CAS No.: 1116454-27-3
• Molecular Formula: C10H20N2O3
• Molecular Weight: 216.28
• Mol file: 1116454-27-3.mol

Synonyms:(2S,4R)-4-acetylthio-1-t-butoxycarbonylpyrrolidine-2-methanol;(2S,4R)-4-amino-2-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester;(2S,4R)-4-amino-2-fluoromethylpyrrolidine-1-carboxylic acid tert-butyl ester;(2S,4R)-TERT-BUTYL 4-(ACETYLTHIO)-2-(HYDROXYMETHYL)PYRROLIDINE-1-CARBOXYLATE;

Chemical Property of (2S,4R)-1-BOC-2-hydroxyMethyl-4-aMino Pyrrolidine-HCl

Chemical Property:

• Boiling Point: 323.3±27.0 °C(Predicted)
• PKA: 14.77±0.10(Predicted)
• PSA: 75.79000
• Density: 1.120±0.06 g/cm3(Predicted)
• LogP: 1.75560

Purity/Quality:

99%, ^*data from raw suppliers

(2S,4R)-1-Boc-2-hydroxymethyl-4-aminopyrrolidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,4R)-1-BOC-2-hydroxyMethyl-4-aMino Pyrrolidine-HCl

There total 2 articles about (2S,4R)-1-BOC-2-hydroxyMethyl-4-aMino Pyrrolidine-HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-tert-butyl 2-methyl (2S,4R)-4-azido-1,2-pyrrolidinedicarboxylate (121147-97-5) → tert-butyl (2S,4R)-4-amino-2-(hydroxymethyl)pyrrolidine-1-carboxylate (1116454-27-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

→ tert-butyl (2S,4R)-4-amino-2-(hydroxymethyl)pyrrolidine-1-carboxylate (1116454-27-3)

Guidance literature:

Reference yield:

tert-butyl (2S,4R)-4-amino-2-(hydroxymethyl)pyrrolidine-1-carboxylate (1116454-27-3) + (2-chloro-4-phenoxy-phenyl)-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone → tert-butyl (2S,4R)-4-((5-(2-chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 80 ℃;

upstream raw materials:

1-tert-butyl 2-methyl (2S,4R)-4-azido-1,2-pyrrolidinedicarboxylate

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