1-(3-chlorophenyl)-7,8-diMethoxy-4,5-dihydro-3H-2,3-benzodiazepin-4-one

Base Information

• Chemical Name: 1-(3-chlorophenyl)-7,8-diMethoxy-4,5-dihydro-3H-2,3-benzodiazepin-4-one
• CAS No.: 474070-11-6
• Molecular Formula: C₁₇H₁₄Cl₂N₂O₂
• Molecular Weight: 349.216
• Mol file: 474070-11-6.mol

Synonyms:4-chloro-1-(3-chlorophenyl)-7,8-dimethoxy-5H-2,3-Benzodiazepine;5H-2,3-Benzodiazepine, 4-chloro-1-(3-chlorophenyl)-7,8-dimethoxy-;1-(3-Chlorophenyl)-7,8-diMethoxy-3H-benzo[d][1,2]diazepin-4(5H)-one;(Z)-1-(3-chlorophenyl)-7,8-diMethoxy-3H-benzo[d][1,2]diazepin-4(5H)-one;1-(3-chlorophenyl)-7,8-diMethoxy-4,5-dihydro-3H-2,3-benzodiazepin-4-one

Chemical Property of 1-(3-chlorophenyl)-7,8-diMethoxy-4,5-dihydro-3H-2,3-benzodiazepin-4-one

Chemical Property:

• PSA: 63.41000
• LogP: 2.49340

Purity/Quality:

97% ^*data from raw suppliers

1-(3-Chlorophenyl)-7,8-dimethoxy-3H-benzo[d][1,2]diazepin-4(5H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-chlorophenyl)-7,8-diMethoxy-4,5-dihydro-3H-2,3-benzodiazepin-4-one

There total 4 articles about 1-(3-chlorophenyl)-7,8-diMethoxy-4,5-dihydro-3H-2,3-benzodiazepin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-chloro-phenyl)-7,8-dimethoxy-3,5-dihydro-benzo[d][1,2]diazepin-4-one → C17H14Cl2N2O2 (474070-11-6)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; In chloroform; at 120 ℃;

DOI:10.1016/j.bmcl.2011.08.036

Reference yield:

C18H17ClO5 (474055-25-9) → C17H14Cl2N2O2 (474070-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 3 h / 150 °C

1.2: 0.5 h / Reflux

2.1: N,N-dimethyl-aniline; trichlorophosphate / chloroform / 120 °C

With hydrazine hydrate; N,N-dimethyl-aniline; trichlorophosphate; In ethanol; chloroform;

DOI:10.1016/j.bmcl.2011.08.036

Reference yield:

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) → C17H14Cl2N2O2 (474070-11-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid / Reflux

2.1: tin(ll) chloride / 20 °C

3.1: hydrazine hydrate / ethanol / 3 h / 150 °C

3.2: 0.5 h / Reflux

4.1: N,N-dimethyl-aniline; trichlorophosphate / chloroform / 120 °C

With sulfuric acid; hydrazine hydrate; N,N-dimethyl-aniline; tin(ll) chloride; trichlorophosphate; In ethanol; chloroform;

DOI:10.1016/j.bmcl.2011.08.036

upstream raw materials:

(3,4-Dimethoxyphenyl)acetic acid

C₁₈H₁₇ClO₅

methyl (3,4-dimethoxyphenyl)acetate

Downstream raw materials:

1-(3-chloro-phenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine

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