(R)-1-(2-Methoxyphenyl)propan-1-amine hydrochloride

Base Information

• Chemical Name: (R)-1-(2-Methoxyphenyl)propan-1-amine hydrochloride
• CAS No.: 623143-38-4
• Molecular Formula: C10H15NO
• Molecular Weight: 165.2322
• DSSTox Substance ID: DTXSID40704212
• Mol file: 623143-38-4.mol

Synonyms:623143-38-4;(R)-1-(2-Methoxyphenyl)propan-1-amine hydrochloride;(1R)-1-(2-Methoxyphenyl)propylamine hydrochloride;(1R)-1-(2-Methoxyphenyl)propylamine HCl;(1R)-1-(2-methoxyphenyl)propan-1-amine;hydrochloride;DTXSID40704212;Benzenemethanamine, alpha-ethyl-2-methoxy-, (alphaR)- (9CI);MFCD12757161;AKOS015923146;BS-17260;Y10283;A868510;(R)-1-(2-Methoxyphenyl)propan-1-aminehydrochloride;(1R)-1-(2-methoxyphenyl)propan-1-amine hydrochloride;(1R)-1-(2-Methoxyphenyl)propan-1-amine--hydrogen chloride (1/1);2103395-82-8

Chemical Property of (R)-1-(2-Methoxyphenyl)propan-1-amine hydrochloride

Chemical Property:

• PSA: 35.25000
• LogP: 3.60730
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 201.0920418
• Heavy Atom Count: 13
• Complexity: 127

Purity/Quality:

99%, ^*data from raw suppliers

(1R)-1-(2-Methoxyphenyl)propylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C1=CC=CC=C1OC)N.Cl
• Isomeric SMILES: CC[C@H](C1=CC=CC=C1OC)N.Cl

Technology Process of (R)-1-(2-Methoxyphenyl)propan-1-amine hydrochloride

There total 6 articles about (R)-1-(2-Methoxyphenyl)propan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-[1-(2'-methoxyphenyl)propyl]amino-3-mercapto-6-methyl-4H-1,2,4-triazin-5-one (918165-81-8) → (1S)-(2'-methoxyphenyl)propylamine (623143-37-3,623143-38-4) + 3,4-dihydro-6-methyl-3-thioxo-1,2,4-triazin-5(2H)-one (615-76-9)

Guidance literature:

With hydrogenchloride; zinc; In ethanol; at 55 - 60 ℃; for 24h;

DOI:10.1016/j.tetasy.2006.10.013

Reference yield:

3-Mercapto-4-{[1-(2-methoxy-phenyl)-meth-(E)-ylidene]-amino}-6-methyl-4H-[1,2,4]triazin-5-one (952576-46-4) → (1S)-(2'-methoxyphenyl)propylamine (623143-37-3,623143-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1: polystyrene-supported (1S,2R)-PhCH₂N(Me)CH(Me)CH(Ph)OH; i-Pr₃SiCl / toluene; hexane / 24 h / -10 °C

2: conc. HCl; Zn / ethanol / 24 h / 55 - 60 °C

With hydrogenchloride; zinc; In ethanol; hexane; toluene;

DOI:10.1016/j.tet.2007.04.041

Reference yield:

ortho-anisaldehyde (135-02-4) → (1S)-(2'-methoxyphenyl)propylamine (623143-37-3,623143-38-4)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / Heating

2: polystyrene-supported (1S,2R)-PhCH₂N(Me)CH(Me)CH(Ph)OH; i-Pr₃SiCl / toluene; hexane / 24 h / -10 °C

3: conc. HCl; Zn / ethanol / 24 h / 55 - 60 °C

With hydrogenchloride; zinc; In methanol; ethanol; hexane; toluene;

DOI:10.1016/j.tet.2007.04.041

upstream raw materials:

1-(2-methoxy-phenyl)-propan-1-one oxime

(S)-4-[1-(2'-methoxyphenyl)propyl]amino-3-mercapto-6-methyl-4H-1,2,4-triazin-5-one

3-Mercapto-4-{[1-(2-methoxy-phenyl)-meth-(E)-ylidene]-amino}-6-methyl-4H-[1,2,4]triazin-5-one

ortho-anisaldehyde

Downstream raw materials:

[1-(2-methoxy-phenyl)-propyl]-dimethyl-amine

Refernces

• 1、 El-Shehawy, Ashraf A.. "Efficient dual catalytic enantioselective diethylzinc addition to the exocyclic C{double bond, long}N double bond of some 1,2,4-N-triazinylarylimines using polymer-supported chiral β-amino alcohols derived from norephedrine". . p. 5490 - 5500. Retrieved 2008/01/07.