6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4-diol

Base Information

Chemical Name:6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4-diol
CAS No.:684202-26-4
Molecular Formula:C6H7N3O2
Molecular Weight:153.14
Hs Code.:
Mol file:684202-26-4.mol

Synonyms:5H-Pyrrolo[3,4-d]pyrimidine-2,4-diol, 6,7-dihydro-; 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4-diol

Suppliers and Price of 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4-diol 97%
250mg
$ 339.00

Chemenu
6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4-diol 97%
250mg
$ 320.00

American Custom Chemicals Corporation
6,7-DIHYDRO-5H-PYRROLO[3,4-D]PYRIMIDINE-2,4-DIOL 95.00%
1G
$ 1247.40

Total 1 raw suppliers

Chemical Property of 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4-diol

Chemical Property:

PKA:10.17±0.20(Predicted)
PSA：77.75000
Density:1.51±0.1 g/cm3(Predicted)
LogP:-1.00480

Purity/Quality:: 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4-diol 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4-diol

There total 4 articles about 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 6-tert-butoxycarbonylpyrrolo[3,4-d]pyrimidin-2,4(1H,3H,5H,7H)-dione

: 684202-26-4
pyrrolo[3,4-d]pyrimidin-2,4(1H,3H,5H,7H)-dione

Guidance literature:: With hydrogenchloride; In methanol; at 0 - 20 ℃; for 3.5h;
DOI:10.1021/acs.jmedchem.8b00099

Reference yield:

: 146256-98-6
4-oxo-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

: 684202-26-4
pyrrolo[3,4-d]pyrimidin-2,4(1H,3H,5H,7H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / ethanol / 12 h / Reflux

2.1: pyridine / 1,2-dichloro-ethane; toluene / 3 h / 0 - 20 °C / Inert atmosphere

2.2: 13 h / -5 - 60 °C

3.1: sodium ethanolate / methanol / 12 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride / methanol / 3.5 h / 0 - 20 °C

With pyridine; hydrogenchloride; ammonium acetate; sodium ethanolate; In methanol; ethanol; 1,2-dichloro-ethane; toluene;
DOI:10.1021/acs.jmedchem.8b00099

Reference yield:

: 951626-01-0
ethyl 1-(tert-butoxycarbonyl)-4-amino-2,5-dihydro-1H-pyrrole-3-carboxylate

: 684202-26-4
pyrrolo[3,4-d]pyrimidin-2,4(1H,3H,5H,7H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 1,2-dichloro-ethane; toluene / 3 h / 0 - 20 °C / Inert atmosphere

1.2: 13 h / -5 - 60 °C

2.1: sodium ethanolate / methanol / 12 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / methanol / 3.5 h / 0 - 20 °C

With pyridine; hydrogenchloride; sodium ethanolate; In methanol; 1,2-dichloro-ethane; toluene;
DOI:10.1021/acs.jmedchem.8b00099