Chemical Property of 3-(4-((3-Phenoxybenzyl)amino)phenyl)propanoic acid
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Boiling Point:538.439°C at 760 mmHg
- Flash Point:279.438°C
- PSA：58.56000
- Density:1.223g/cm3
- LogP:5.18120
- Storage Temp.:Store at RT
- Solubility.:DMSO: >20mg/mL
- XLogP3:4.7
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:8
- Exact Mass:347.15214353
- Heavy Atom Count:26
- Complexity:414
- Purity/Quality:
-
99%, *data from raw suppliers
GW9508 *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn,N
- Hazard Codes:Xn,N
- Statements:
22-37/38-41-50/53
- Safety Statements:
26-39-60-61
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
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Description
GW9508 (885101-89-3) is a selective agonist at the free fatty acid receptor, FFA1/4, (GPR40 and GPR120).1 Displays anti-allodynic and anti-hyperalgesic effects in mouse inflammatory and neuropathic pain models.2 Inhibits LPA-induced proliferation of DU145 and PC-3 cells.3 Decreases hepatic lipid accumulation in a high fat diet steatosis mouse model.4 Promotes brown adipose tissue thermogenesis.5
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Uses
GW9508 is a GPR40 full agonist, used to regulate glucose in rats. Can be applied to the treatment of diabetes type 2. GPR120 selective and potent agonist also used in the treatment of diabetes type 2 due to GPR120’s ability to mediate GLP-1 secretion, insulin sensitization and anti-obesity effects. GW9508, a selective FFA1/GPR40 agonist, may be used to differentiate and characterize the free fatty acid receptor FFA1/GPR40. GW9508 is used to study the role of FFA1/GPR40 receptors in processes such as the free fatty acid enhancement of glucose-stimulated insulin release and type 2 diabetes. GW9508 is used to study the process by which FFA1/GPR40 receptors protect from ovariectomy-induced bone loss in vivo though inhibition of osteoclast differentiation and suppress complete Freund′s adjuvant (CFA)-Induced inflammatory chronic pain.
