D-CAMPHOLIC ACID

Base Information

• Chemical Name: D-CAMPHOLIC ACID
• CAS No.: 31147-56-5
• Molecular Formula: C10H18O2
• Molecular Weight: 170.25
• Mol file: 31147-56-5.mol

Synonyms:1,2,2,3-Tetramethylcyclopentanecarboxylic acid;D-trans-1,2,2,3-Tetramethylcyclopentanecarboxylic acid;(1R,3R)-1,2,2,3-Tetramethylcyclopentanecarboxylic acid;[1R,(+)]-1,2,2,3α-Tetramethylcyclopentane-1β-carboxylic acid;

Chemical Property of D-CAMPHOLIC ACID

Chemical Property:

• Vapor Pressure: 0.00779mmHg at 25°C
• Boiling Point: 248.4°C at 760 mmHg
• Flash Point: 120.5°C
• PSA: 37.30000
• Density: 0.957g/cm³
• LogP: 2.53340

Purity/Quality:

98%Min ^*data from raw suppliers

(1R,3S)-1,2,2,3-tetramethylcyclopentane-1-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-CAMPHOLIC ACID

There total 1 articles about D-CAMPHOLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one (736109-58-3,787517-91-3,68546-28-1) → (+)-isocampholic acid (464-88-0,31147-56-5)

Guidance literature:

Reaktion ueber mehrere Stufen;

Reference yield:

C10H18O2 (31147-56-5) → 2-(1R,3R-1,2,2,3-tetramethylcyclopentyl)-4,6-diphenylpyridine (1403575-89-2)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / 1 h / Inert atmosphere

2: boron trifluoride diethyl etherate / 2 h / 100 °C

3: ammonium hydroxide / diethyl ether / 6 h / Reflux

With ammonium hydroxide; oxalyl dichloride; boron trifluoride diethyl etherate; N,N-dimethyl-formamide; In diethyl ether;

DOI:10.1016/j.tetlet.2012.08.006

Reference yield:

C10H18O2 (31147-56-5) → 2-(1,2,2,3-tetramethylcyclopentyl)-4,6-diphenylphosphinine (1403575-67-6)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / 1 h / Inert atmosphere

2: boron trifluoride diethyl etherate / 2 h / 100 °C

3: Tris(trimethylsilyl)phosphane / acetonitrile; hexane / 24 h / Inert atmosphere; Reflux

With oxalyl dichloride; Tris(trimethylsilyl)phosphane; boron trifluoride diethyl etherate; N,N-dimethyl-formamide; In hexane; acetonitrile;

DOI:10.1016/j.tetlet.2012.08.006

upstream raw materials:

1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one

Downstream raw materials:

2-(1R,3R-1,2,2,3-tetramethylcyclopentyl)-4,6-diphenylpyridine

2-(1R,3R-1,2,2,3-tetramethylcyclopentyl)-4,6-diphenylpyrylium tetrafluoroborate

2-(1,2,2,3-tetramethylcyclopentyl)-4,6-diphenylphosphinine