PDDHV

Base Information

• Chemical Name: PDDHV
• CAS No.: 179469-40-0
• Molecular Formula: C49H72O11
• Molecular Weight: 837.09
• Mol file: 179469-40-0.mol

Synonyms:PHORBOL 12,13-DIDECANOATE 20-HOMOVANILLATE;

Chemical Property of PDDHV

Chemical Property:

• PSA: 165.89000
• LogP: 8.82110
• Storage Temp.: −20°C

Purity/Quality:

≥99% ^*data from raw suppliers

PDDHV ≥99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+
• Statements: 26/27/28-36/37/38
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Description: PDDHV is a resiniferatoxin-type phorboid vanilloid with capsaicin-like selectivity for the cloned rat transient receptor potential cation channel subfamily V member 1 (TRPV1), formerly known as vanilloid receptor 1. It induces Ca2+-uptake by rat dorsal root ganglion neurons with an EC50 value of 70 nM.

Technology Process of PDDHV

There total 1 articles about PDDHV which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Homovanillic acid (306-08-1) + Phorbol-12,13-didecanoate → phorbol 12,13-didecanoate 20 homovanillate (179469-40-0)

Guidance literature:

With 2-fluoro-methylpyridinium tosylate; triethylamine; Yield given. Multistep reaction; 1.) DMF, RT, 30 min, 2.) DMF, 60 deg C, 2 h;

DOI:10.1021/jm960139d

upstream raw materials:

Homovanillic acid

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