9(R)-Hete

Base Information

Chemical Name:9(R)-Hete
CAS No.:107656-14-4
Molecular Formula:C₂₀H₃₂O₃
Molecular Weight:320.472
Hs Code.:
DSSTox Substance ID:DTXSID401185849
Metabolomics Workbench ID:2647
Mol file:107656-14-4.mol

Synonyms:9(R)-Hete;107656-14-4;9R-HETE;(5Z,7E,9R,11Z,14Z)-9-hydroxyicosa-5,7,11,14-tetraenoic acid;9R-hydroxy-5Z,7E,11Z,14Z-eicosatetraenoic acid;CHEBI:165288;DTXSID401185849;LMFA03060026;AKOS040755805;PD020976;SR-01000946919;SR-01000946919-1;9(R)-hydroxy-5(Z),7(E),11(Z),14(Z)-eicosatetraenoic acid;(5Z,7E,9R,11Z,14Z)-9-Hydroxy-5,7,11,14-eicosatetraenoic acid

Suppliers and Price of 9(R)-Hete

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
9(R)-HETE ≥98%
100μg
$ 432.00

Cayman Chemical
9(R)-HETE ≥98%
50μg
$ 228.00

Cayman Chemical
9(R)-HETE ≥98%
25μg
$ 120.00

American Custom Chemicals Corporation
9R-HYDROXY-5Z,7E,11Z,14Z-EICOSATETRAENOIC ACID 95.00%
5MG
$ 499.30

Total 5 raw suppliers

Chemical Property of 9(R)-Hete

Chemical Property:

Boiling Point:487.7±33.0 °C(Predicted)
PKA:4.73±0.10(Predicted)
PSA：57.53000
Density:0.984±0.06 g/cm3(Predicted)
LogP:5.18750
XLogP3:5.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:14
Exact Mass:320.23514488
Heavy Atom Count:23
Complexity:392

Purity/Quality:

98% ^*data from raw suppliers

9(R)-HETE ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC=CCC=CCC(C=CC=CCCCC(=O)O)O
Isomeric SMILES:CCCCC/C=C\C/C=C\C[C@H](/C=C/C=C\CCCC(=O)O)O

Technology Process of 9(R)-Hete

There total 19 articles about 9(R)-Hete which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65090-68-8
dodeca-3,6-diyn-1-ol

: 70968-92-2,107656-13-3,79495-85-5,107656-14-4
+/-9-HETE

Guidance literature:: Multi-step reaction with 14 steps

1: paralleled the route described for diazo-ketone 6

2: 2

3: NaBH₄/CeCl₃ / propan-2-ol; H₂O / 0 °C

4: pyridine / -10 °C

5: imidazole / dimethylformamide / 0 °C

6: H₂ / Lindlar / hexane; pyridine

7: 80percent AcOH / tetrahydrofuran; H₂O

8: 95 percent / CBr₄(Ph₂PCH₂)2 / CH₂Cl₂ / 0 °C

9: 50 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -40 deg C to RT, overnight

10: DCC/py/TFA / benzene; dimethylsulfoxide / 16 h / Ambient temperature

11: NaClO₂ / 2-methyl-propan-2-ol; H₂O

13: 81 percent / n-Bu₄NF / tetrahydrofuran

14: LiOH / 1,2-dimethoxy-ethane; H₂O

With pyridine; 1H-imidazole; lithium hydroxide; sodium chlorite; sodium tetrahydroborate; cerium(III) chloride; CBr₄(Ph₂PCH₂)2; tetrabutyl ammonium fluoride; hydrogen; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; dirhodium tetraacetate; Lindlar's catalyst; In tetrahydrofuran; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4039(01)91141-4

Reference yield:

: 89682-62-2
1-Diazo-trideca-4,7-diyn-2-one

: 70968-92-2,107656-13-3,79495-85-5,107656-14-4
+/-9-HETE

Guidance literature:: Multi-step reaction with 13 steps

1: 2

2: NaBH₄/CeCl₃ / propan-2-ol; H₂O / 0 °C

3: pyridine / -10 °C

4: imidazole / dimethylformamide / 0 °C

5: H₂ / Lindlar / hexane; pyridine

6: 80percent AcOH / tetrahydrofuran; H₂O

7: 95 percent / CBr₄(Ph₂PCH₂)2 / CH₂Cl₂ / 0 °C

8: 50 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -40 deg C to RT, overnight

9: DCC/py/TFA / benzene; dimethylsulfoxide / 16 h / Ambient temperature

10: NaClO₂ / 2-methyl-propan-2-ol; H₂O

12: 81 percent / n-Bu₄NF / tetrahydrofuran

13: LiOH / 1,2-dimethoxy-ethane; H₂O

With pyridine; 1H-imidazole; lithium hydroxide; sodium chlorite; sodium tetrahydroborate; cerium(III) chloride; CBr₄(Ph₂PCH₂)2; tetrabutyl ammonium fluoride; hydrogen; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; dirhodium tetraacetate; Lindlar's catalyst; In tetrahydrofuran; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4039(01)91141-4

Reference yield:

: 89682-65-5
(2Z,4E)-Heptadeca-2,4-diene-8,11-diyne-1,6-diol

: 70968-92-2,107656-13-3,79495-85-5,107656-14-4
+/-9-HETE

Guidance literature:: Multi-step reaction with 11 steps

1: pyridine / -10 °C

2: imidazole / dimethylformamide / 0 °C

3: H₂ / Lindlar / hexane; pyridine

4: 80percent AcOH / tetrahydrofuran; H₂O

5: 95 percent / CBr₄(Ph₂PCH₂)2 / CH₂Cl₂ / 0 °C

6: 50 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -40 deg C to RT, overnight

7: DCC/py/TFA / benzene; dimethylsulfoxide / 16 h / Ambient temperature

8: NaClO₂ / 2-methyl-propan-2-ol; H₂O

10: 81 percent / n-Bu₄NF / tetrahydrofuran

11: LiOH / 1,2-dimethoxy-ethane; H₂O

With pyridine; 1H-imidazole; lithium hydroxide; sodium chlorite; CBr₄(Ph₂PCH₂)2; tetrabutyl ammonium fluoride; hydrogen; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; Lindlar's catalyst; In tetrahydrofuran; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4039(01)91141-4