[METHYL-D3]METANICOTINE

Base Information

Chemical Name:[METHYL-D3]METANICOTINE
CAS No.:220088-40-4
Molecular Formula:C10H11D3N2
Molecular Weight:165.25
Hs Code.:
Mol file:220088-40-4.mol

Synonyms:[METHYL-D3]RJR2403;(E)-N-[METHYL-D3]-4-(3-PYRIDINYL)-3-BUTEN-1-AMINE;(E)-N-[Methyl-d3]-4-(3-pyridinyl)-3-buten-1-amine, [Methyl-d3]RJR2403;

Suppliers and Price of [METHYL-D3]METANICOTINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
Metanicotine-d3
1 mg
$ 450.00

American Custom Chemicals Corporation
(METHYL-D3)METANICOTINE 95.00%
50MG
$ 1963.50

American Custom Chemicals Corporation
(METHYL-D3)METANICOTINE 95.00%
5MG
$ 786.50

aablocks
[Methyl-d3]metanicotine
10mg
$ 2050.00

aablocks
[Methyl-d3]metanicotine
1mg
$ 613.00

Total 6 raw suppliers

Chemical Property of [METHYL-D3]METANICOTINE

Chemical Property:

Boiling Point:99-101°C/0.4mm Hg
PSA：24.92000
LogP:2.09520
Storage Temp.:Amber Vial, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform, Methanol

Purity/Quality:

99% ^*data from raw suppliers

Metanicotine-d3 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses An alkaloid found in the leaves of Duboisia Hopwoodii, and a constitutent of tobacco smoke. Also used a potential drug for the treatment of senile dementia of the Alzheimer type and currently being investigated as a nicotinic agonist with CNS sel [METHYL-D3]METANICOTINE is an alkaloid found in the leaves of Duboisia Hopwoodii, and a constitutent of tobacco smoke. Also used a potential drug for the treatment of senile dementia of the Alzheimer’s type and currently being investigated as a nicotinic agonist with CNS selectivi. An alkaloid found in the leaves of Duboisia Hopwoodii, and a constitutent of tobacco smoke. Also used a potential drug for the treatment of senile dementia of the Alzheimer’s type and currently being investigated as a nicotinic agonist with CNS selectivity. Metanicotine may have clinical potential due to its high selectivity for CNS nicotinic acetylcholine receptor subtypes relative to peripheral ganglionic and muscle-type nicotinic acetylcholine receptors.

Technology Process of [METHYL-D3]METANICOTINE

There total 4 articles about [METHYL-D3]METANICOTINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 220088-39-1
(E)-N-[methyl-d3]-N-ethyloxycarbonyl-4-(3-pyridinyl)-3-buten-1-amine

: 220088-40-4
(E)-N-[methyl-d3]-4-(3-pyridinyl)-3-buten-1-amine

Guidance literature:: With hydrogenchloride; for 20h; Heating;
DOI:10.1002/(SICI)1099-1344(199812)41:12<1165::AID-JLCR162>3.0.CO;2-G

Reference yield:

: 5746-86-1,13450-58-3
rac-nornicotine

: 220088-40-4
(E)-N-[methyl-d3]-4-(3-pyridinyl)-3-buten-1-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran / 0.25 h / -70 °C

1.2: 91 percent / -70 - 0 °C

2.1: 75 percent / CH₂Cl₂ / 4 h / Heating

3.1: 77 percent / 0.5 Torr / Heating

4.1: 84 percent / aq. HCl / 20 h / Heating

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; dichloromethane; 1.1: Metallation / 1.2: Substitution / 2.1: Ring cleavage / 3.1: Dehydrochlorination / 4.1: Hydrolysis;
DOI:10.1002/(SICI)1099-1344(199812)41:12<1165::AID-JLCR162>3.0.CO;2-G

Reference yield:

: 69980-24-1
rac-N-[methyl-d3]nicotine

: 220088-40-4
(E)-N-[methyl-d3]-4-(3-pyridinyl)-3-buten-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / CH₂Cl₂ / 4 h / Heating

2: 77 percent / 0.5 Torr / Heating

3: 84 percent / aq. HCl / 20 h / Heating

With hydrogenchloride; In dichloromethane; 1: Ring cleavage / 2: Dehydrochlorination / 3: Hydrolysis;
DOI:10.1002/(SICI)1099-1344(199812)41:12<1165::AID-JLCR162>3.0.CO;2-G