GW791343 (HCl)

Base Information

Chemical Name:GW791343 (HCl)
CAS No.:1019779-04-4
Molecular Formula:C20H24F2N4O.2ClH
Molecular Weight:374.4275664
Hs Code.:
Mol file:1019779-04-4.mol

Synonyms:GW791343 (HCl);2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamidetrihydrochloride;GW 791343 hydrochloride;2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]acetamide hydrochloride;GW 791343

Suppliers and Price of GW791343 (HCl)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
GW 791343 hydrochloride
10mg
$ 466.00

TRC
GW791343Hydrochloride
10mg
$ 145.00

TRC
GW791343Hydrochloride
25mg
$ 295.00

Tocris
GW791343hydrochloride ≥99%(HPLC)
10
$ 185.00

Tocris
GW791343hydrochloride ≥99%(HPLC)
50
$ 729.00

Crysdot
GW791343dihydrochloride 98+%
50mg
$ 385.00

Crysdot
GW791343dihydrochloride 98+%
5mg
$ 69.00

Crysdot
GW791343dihydrochloride 98+%
10mg
$ 98.00

ChemScene
GW791343dihydrochloride 98.03%
10mg
$ 144.00

ChemScene
GW791343dihydrochloride 98.03%
5mg
$ 84.00

Total 25 raw suppliers

Chemical Property of GW791343 (HCl)

Chemical Property:

PSA：56.40000
LogP:5.54770
Storage Temp.:Desiccate at RT

Purity/Quality:

97% ^*data from raw suppliers

GW 791343 hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses GW 791343 DTrihydrochloride is a P2X7 receptor antagonist that acts as an allosteric inhibitor, exhibiting negative allosteric effects at the human P2X7 receptor and positive allosteric effects at the rat P2X7 receptor. P2X7 receptor is responsible for the presence of inflammatory cells, regulated by extracellular ATP. GW 791343 Hydrochloride is a P2X7 allosteric modulator.

Technology Process of GW791343 (HCl)

There total 6 articles about GW791343 (HCl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 309712-84-3
4-(3-{2-[-tert-Butoxycarbonyl-(3,4-difluoro-phenyl)-amino]-acetylamino}-4-methyl-benzyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1019779-04-4
GW 791343

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; acetone;

Reference yield:

: 309712-80-9
[tert-butoxycarbonyl-(3,4-difluorophenyl)-amino]-acetic acid methyl ester

: 1019779-04-4
GW 791343

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydrogensulfate; lithium hydroxide monohydrate / tetrahydrofuran; water

2: triethylamine / tetrahydrofuran; methanol; dichloromethane

3: hydrogenchloride / 1,4-dioxane; methanol; acetone

With hydrogenchloride; potassium hydrogensulfate; lithium hydroxide monohydrate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetone;

Reference yield:

: 309712-82-1
4-(4-methyl-3-nitro-benzyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1019779-04-4
GW 791343

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium chloride / ethanol; water; ethyl acetate

2: triethylamine / tetrahydrofuran; methanol; dichloromethane

3: hydrogenchloride / 1,4-dioxane; methanol; acetone

With hydrogenchloride; ammonium chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; acetone;