Chemical Property of Brevianamide F
Chemical Property:
- Vapor Pressure:6.11E-16mmHg at 25°C
- Melting Point:165-167 °C
- Boiling Point:633.2°C at 760 mmHg
- PKA:13.20±0.40(Predicted)
- Flash Point:336.8°C
- PSA：68.69000
- Density:1.37g/cm3
- LogP:1.41360
- Storage Temp.:2-8°C
- Solubility.:Chloroform (Slightly), Methanol (Slightly)
- XLogP3:1.5
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:2
- Exact Mass:283.132076794
- Heavy Atom Count:21
- Complexity:453
- Purity/Quality:
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97% *data from raw suppliers
BrevianamideF *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CC2C(=O)NC(C(=O)N2C1)CC3=CNC4=CC=CC=C43
- Isomeric SMILES:C1C[C@H]2C(=O)N[C@H](C(=O)N2C1)CC3=CNC4=CC=CC=C43
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Description
Brevianamide F is an alkaloid metabolite produced by various Streptomyces, Actinomycetes, and Aspergillus strains that has diverse biological activities. It inhibits growth of M. luteus and S. aureus in an inhibitory disc assay when used at a concentration of 30 μg/disc as well as the Bacille Calmette-Guerin M. bovis strain (MIC = 12.5 μg/ml). Brevianamide F has antifouling activity, inhibiting attachment of B. neritina larvae to PVC plates without inducing lethality (EC50 = 6.35 μg/ml; LC50 = >200 μg/ml in paint used to coat PVC plates).
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Uses
Brevianamide F is used in the preparation, reactions, medicinal and cheical propreties of diketopiperazines as bioactive natural products. Acts as a reagent in the total synthesis and antitumor activity in vitro of glioperazine C and its derivatives, synthesis and biological evaluation of a post-synthetically trp-based diketopiperazine and it’s antitumor structure-activity relationship.
