2,3,5-trifluoro-4-iodopyridine

Base Information

• Chemical Name: 2,3,5-trifluoro-4-iodopyridine
• CAS No.: 1057393-65-3
• Molecular Formula: C5HF3IN
• Molecular Weight: 258.9678196
• Mol file: 1057393-65-3.mol

Synonyms:2,3,5-trifluoro-4-iodopyridine

Chemical Property of 2,3,5-trifluoro-4-iodopyridine

Chemical Property:

• Boiling Point: 192.7±35.0 °C(Predicted)
• PKA: -6.67±0.28(Predicted)
• PSA: 12.89000
• Density: 2.206±0.06 g/cm3(Predicted)
• LogP: 2.10350
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99%+, ^*data from raw suppliers

2,3,5-Trifluoro-4-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,5-trifluoro-4-iodopyridine

There total 2 articles about 2,3,5-trifluoro-4-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

→ 2,3,5-trifluoro-4-iodopyridine (1057393-65-3)

Guidance literature:

Reference yield: 53.85%

2,3,5‐trifluoropyridine (76469-41-5) → 2,3,5-trifluoro-4-iodopyridine (1057393-65-3)

Guidance literature:

2,3,5‐trifluoropyridine; With n-butyllithium; In tetrahydrofuran; hexane; for 2.5h; Inert atmosphere; Schlenk technique;

With iodine; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.7b02267

Reference yield: 84.0%

2,3,5-trifluoro-4-iodopyridine (1057393-65-3) + 3,4,5-trifluorophenylboronic acid (143418-49-9) → 2,3,5-trifluoro-4-(3,4,5-trifluorophenyl)pyridine

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; CyJohnPhos; In tetrahydrofuran; water; toluene; at 95 ℃; for 60h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.7b02267

upstream raw materials:

2,3,5‐trifluoropyridine

Refernces

• 1、 Aiguadé, Josep,Balagué, Cristina,Carranco, Inés,Caturla, Francisco,Domínguez, María,Eastwood, Paul,Esteve, Cristina,González, Jacob,Lumeras, Wenceslao,Orellana, Adelina,Preciado, Sara,Roca, Ramón,Vidal, Laura,Vidal, Bernat. "Novel triazolopyridylbenzamides as potent and selective p38α inhibitors". scheme or table. p. 3431 - 3436. Retrieved 2012/06/18.