1,4,8-Trioxaspiro[4.5]decane-7,9-dione

Base Information

• Chemical Name: 1,4,8-Trioxaspiro[4.5]decane-7,9-dione
• CAS No.: 32296-88-1
• Molecular Formula: C₇H₈O₅
• Molecular Weight: 172.138
• Mol file: 32296-88-1.mol

Synonyms:[1,3]Dioxolane-2,2-diyl-bis-acetic acid anhydride;

Chemical Property of 1,4,8-Trioxaspiro[4.5]decane-7,9-dione

Chemical Property:

• Melting Point: 111-112 °C
• Boiling Point: 364.0±42.0 °C
• Flash Point: 167.6±27.9 °C
• PSA: 61.83000
• Density: 1.42
• LogP: -0.40690

Purity/Quality:

99% ^*data from raw suppliers

1,4,8-TRIOXASPIRO[4.5]DECANE-7,9-DIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4,8-Trioxaspiro[4.5]decane-7,9-dione

There total 3 articles about 1,4,8-Trioxaspiro[4.5]decane-7,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,2'-(1,3-dioxolane-2,2-diyl)diacetic acid (5694-91-7) → 3,3-(ethylenedioxy)glutaric anhydride (32296-88-1)

Guidance literature:

With trimethylsilylethoxyacetylene; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jo00372a010

Reference yield:

diethyl 2,2'-(1,3-dioxolane-2,2-diyl)diacetate (71022-90-7) → 3,3-(ethylenedioxy)glutaric anhydride (32296-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / aq. KOH / ethanol / Heating

2: 100 percent / (trimethylsilyl)ethoxyacetylene / CH₂Cl₂ / 2 h / 20 °C

With potassium hydroxide; trimethylsilylethoxyacetylene; In ethanol; dichloromethane;

DOI:10.1021/jo00372a010

Reference yield:

→ 3,3-(ethylenedioxy)glutaric anhydride (32296-88-1)

Guidance literature:

/BRN= 52980/, Oxalylchlorid;

DOI:10.1021/jo00967a024

upstream raw materials:

2,2'-(1,3-dioxolane-2,2-diyl)diacetic acid

diethyl 2,2'-(1,3-dioxolane-2,2-diyl)diacetate

Downstream raw materials:

{2-[2-(2,4-Dihydroxy-6-methyl-phenyl)-2-oxo-ethyl]-[1,3]dioxolan-2-yl}-acetic acid

Refernces

• 1、 Kita, Y.,Akai, S.,Yoshigi, M.,Nakajima, Y.,Yasuda, H.,Tamura, Y.. "A MILD AND FACILE SYNTHESIS OF CARBOXYLIC ANHYDRIDES". . p. 6027 - 6030. Retrieved 2007/10/02.