6-Trifluoromethyl-3-pyridinesulfonyl Chloride

Base Information

• Chemical Name: 6-Trifluoromethyl-3-pyridinesulfonyl Chloride
• CAS No.: 959996-58-8
• Molecular Formula: C6H3ClF3NO2S
• Molecular Weight: 245.61
• Hs Code.: 2933399090
• Mol file: 959996-58-8.mol

Synonyms:3-pyridinesulfonyl chloride, 6-(trifluoromethyl)-

Chemical Property of 6-Trifluoromethyl-3-pyridinesulfonyl Chloride

Chemical Property:

• Vapor Pressure: 0.015mmHg at 25°C
• Melting Point: 42-45℃
• Boiling Point: 265.488°C at 760 mmHg
• Flash Point: 114.364°C
• PSA: 55.41000
• Density: 1.607g/cm³
• LogP: 3.10870
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

6-Trifluoromethyl-3-pyridinesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Trifluoromethyl-3-pyridinesulfonyl Chloride is used for the preparation of N-sulfonamido polycyclic pyrazolyl compounds for treatment of cognitive disorders. 6-Trifluoromethyl-3-pyridinesulfonyl Chloride is a chemical used for the preparation of N-sulfonamido polycyclic pyrazolyl compounds for treatment of cognitive disorders.

Technology Process of 6-Trifluoromethyl-3-pyridinesulfonyl Chloride

There total 1 articles about 6-Trifluoromethyl-3-pyridinesulfonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

6-(trifluoromethyl)pyridin-3-amine (106877-33-2) → 6-(trifluoromethyl)pyridine-3-sulfonyl chloride (959996-58-8)

Guidance literature:

With thionyl chloride; copper(l) chloride; In water; at 0 - 5 ℃;

6-(trifluoromethyl)pyridin-3-amine; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃; for 0.5h;

Reference yield: 88.0%

6-(trifluoromethyl)pyridine-3-sulfonyl chloride (959996-58-8) + C11H12ClF2NO2*ClH (1415916-26-5) → C17H14ClF5N2O4S (1415916-27-6)

Guidance literature:

In pyridine;

DOI:10.1248/cpb.c110498

Reference yield: 73.0%

6-(trifluoromethyl)pyridine-3-sulfonyl chloride (959996-58-8) + 2-fluoro-4-(((3S,4R)-4-hydroxy-4-((R)-1-hydroxyethyl)pyrrolidin-3-yl)oxy)benzonitrile → 2-fluoro-4-(((3S,4R)-4-hydroxy-4-((R)-1-hydroxyethyl)-1-((6-(trifluoromethyl)pyridin-3-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 72h; pH=8;

upstream raw materials:

6-(trifluoromethyl)pyridin-3-amine

Downstream raw materials:

(R)-N-((3-(2-bromo-5-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-6-(trifluoromethyl)pyridine-3-sulfonamide

N-(4-((3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxyphenylsulfonamido)methyl)benzyl)-N-(4-fluorobenzyl)-6-(trifluoromethyl)pyridine-3-sulfonamide

N-((1R,2R)-2-(hydroxymethyl)cyclohexyl)-6-(trifluoromethyl)pyridine-3-sulfonamide

N-((1R)-(5-(2-bromo-5-fluorophenyl)-1-tert-butyl-1H-pyrazol-4-yl)(cyclopropyl)methyl)-6-(trifluoromethyl)pyridine-3-sulfonamide

Refernces

• 1、 -. "Fused, Tricyclic Sulfonamide Inhibitors of Gamma Secretase". Page/Page column 88; 89. . Retrieved 2008/06/13.