Chemical Property of Neohesperidin
Chemical Property:
- Appearance/Colour:white powder
- Vapor Pressure:0mmHg at 25°C
- Melting Point:239-243 ºC
- Refractive Index:1.695
- Boiling Point:933.7 ºC at 760 mmHg
- PKA:7.14±0.40(Predicted)
- Flash Point:306.7 ºC
- PSA：234.29000
- Density:1.65 g/cm3
- LogP:-1.15660
- Storage Temp.:2-8°C
- Solubility.:DMSO (Slightly), Pyridine (Slightly)
- Water Solubility.:3.98mg/L at 20℃
- XLogP3:-0.5
- Hydrogen Bond Donor Count:8
- Hydrogen Bond Acceptor Count:15
- Rotatable Bond Count:7
- Exact Mass:610.18977037
- Heavy Atom Count:43
- Complexity:940
- Purity/Quality:
-
99% *data from raw suppliers
Neohesperidin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)CO)O)O)O)O)O
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Description
Neohesperidin is a flavonoid found in citrus fruit peel that has diverse biological activities. In vitro, it inhibits osteoclast differentiation, bone resorption, calcium oscillations, and activation of NF-κB and nuclear factor of activated T cells (NFAT) by receptor activator of NF-κB ligand (RANKL). In vivo, neohesperidin administration protects ovariectomized mice from bone loss. Neohesperidin acts as a hypolipidemic agent, reducing lipid accumulation in HepG2 cells and reversing hyperlipidemia in a mouse model of diet-induced obesity. In a mouse model of diabetes, neohesperidin increases glucose tolerance and decreases insulin resistance while simultaneously decreasing serum triglycerides and total cholesterol and inhibiting lipid accumulation in livers in vivo.
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Uses
Neohesperidin can be used in cosmetic products and as a sweetening agent in food & beverages, an antioxidant flavanone glycoside An antioxidant flavanone glycoside Neohesperidin exhibits lipid-regulating effects in vivo and in vitro. It is a main flavonoid in citrus byproducts (CBP) which possesses anti-oxidant activity.
